{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:40:07Z","timestamp":1698471607964},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":3622,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiotypes (Id) that stimulate immunoregulatory anti\u2010Id T lymphocyte proliferation are expressed on murine and human antibodies (Ab) to soluble egg antigens (SEA) of <jats:italic>Schistosoma mansoni.<\/jats:italic> Kinetics of early expression of these stimulatory Id have now been studied using immunoaffinity\u2010purified serum anti\u2010SEA Ab from mice infected with <jats:italic>S. mansoni<\/jats:italic> for 6, 7, 8, 12, or 16 weeks. Rabbit anti\u2010Id Ab specific for mouse anti\u2010SEA Id expressed at 8 weeks post\u2010infection (anti\u20108WkId) demonstrated the strongest interactions with Id present at 7 and 8 weeks post\u2010infection by competitive enzyme\u2010linked immunosorbent assay. Anti\u20108WkId Ab reacted progressively less well with 12WkId, 6WkId, and 16WkId. Splenocytes from mice infected for 8 weeks demonstrated the highest blast transformation responses <jats:italic>in vitro<\/jats:italic> to anti\u2010SEA Id from mice infected for 6 weeks, while 7, 8, 12, and 16 weeks post\u2010infection Id preparations stimulated progressively less proliferation. These data indicate that although eventual Id\u2010associated immunoregulatory events contribute to chronicity in this disease, production of anti\u2010SEA Ab that express stimulatory cross\u2010reactive immunoregulatory Id comprises a substantial portion of the initial, acute anti\u2010SEA response in mice infected with <jats:italic>Schistosoma mansoni.<\/jats:italic> Furthermore, either this particular Id\u2010expressing response is not maintained, or its proportional presence is greatly diminished by the cumulative production of other multiple anti\u2010SEA Ab during the establishment of chronicity, perhaps in response to its immunoregulatory influence very early in infection.<\/jats:p>","DOI":"10.1002\/eji.1830260143","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:16:14Z","timestamp":1172798174000},"page":"272-275","source":"Crossref","is-referenced-by-count":2,"title":["Early development and progression of lymphocyte\u2010stimulatory cross\u2010reactive idiotypes expressed on antibodies to soluble egg antigens during <i>Schistosoma mansoni<\/i> infection of mice"],"prefix":"10.1002","volume":"26","author":[{"given":"Stephen C.","family":"Bosshardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A.","family":"Nix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Colley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"359","volume":"12","author":"Damian R. 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