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Vascular adhesion protein\u20101 (VAP\u20101) is a 170\u2013180\/90\u2010kDa endothelial molecule expressed most prominently in high endothelial venules in peripheral lymph node (PLN) type lymphatic tissues. VAP\u20101 mediates lymphocyte binding to PLN, tonsil and synovium. The expression of VAP\u20101 is induced in inflammatory diseases such as arthritis and gut inflammation. We examined the expression, structure and function of VAP\u20101 in normal and inflamed skin and compared it to those of other adhesion molecules implicated in skin homing. In psoriasis, lichen ruber planus, pemphigoid and allergic lesions, VAP\u20101 was markedly up\u2010regulated. The expression of VAP\u20101 was also increased in biopsies of healthy skin of the patients. The VAP\u20101 molecule induced in skin is decorated with abundant sialic acids. VAP\u20101 in inflamed skin is functional, since inhibition with anti\u2010VAP\u20101 monoclonal antibodies caused a 60% reduction in lymphocyte adhesion to vascular endothelium. Antibodies against E\u2010selectin, which has been regarded as the major vascular addressin directing cutaneous lymphocyte traffic, and, surprisingly, against peripheral lymph node addressin (PNAd), caused inhibitions of 30% and 60%, respectively, in the frozen section adhesion assay. These findings suggest important roles also for VAP\u20101 and PNAd in lymphocyte homing into inflamed skin.<\/jats:p>","DOI":"10.1002\/eji.1830260415","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:49:11Z","timestamp":1172800151000},"page":"825-833","source":"Crossref","is-referenced-by-count":52,"title":["Lymphocyte binding to vascular endothelium in inflamed skin revisited: a central role for vascular adhesion protein\u20101 (VAP\u20101)"],"prefix":"10.1002","volume":"26","author":[{"given":"Anna\u2010Maija","family":"Arvilommi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Salmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsti","family":"Kalimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirpa","family":"Jalkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00200534"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90279-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1182\/blood.V84.7.2068.2068","volume":"7","author":"Carlos T. 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