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This incongruity suggests that Fas may elicit signaling events that overlap with those used by proliferation cues. We observe that in the human T cell line Jurkat and in human peripheral blood lymphocytes, Fas stimulation does not signal by the Ras\/Raf\u20101\/mitogen\u2010activated protein kinase (MAPK) pathway or by increased intracellular calcium. Rather, Fas ligation strongly activates Jun kinase (JNK). This activity, as well as Fas\u2010induced apoptosis, is blocked by increased levels of cAMP. The balance between proliferation and apoptosis by Fas triggering of T lymphocytes may therefore reflect a signaling ratio between TCR activation of the Ras\/Raf\u20101\/MAPK pathway versus JNK activation by Fas.<\/jats:p>","DOI":"10.1002\/eji.1830260505","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:03:19Z","timestamp":1172800999000},"page":"989-994","source":"Crossref","is-referenced-by-count":120,"title":["JNK, but not MAPK, activation is associated with Fas\u2010mediated apoptosis in human T cells"],"prefix":"10.1002","volume":"26","author":[{"given":"David J.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Fortner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R.","family":"Mattingly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G.","family":"Macara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Posada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph C.","family":"Budd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90614-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2787530"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/377630a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5239.1189"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.8.3806"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90071-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90072-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11894"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7536343"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90143-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2231"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/346719a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90056-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90380-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1313186"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)35739-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(94)90132-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82362-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.4.1199"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1994.tb00885.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0021-9258(18)82367-5","volume":"268","author":"Raines M. 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