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In combination with interleukin (IL)\u20104, sCD40L had limited additive effects on CD25 expression, but significantly enhanced CD23 expression on tonsillar B cells. Interferon\u2010\u03b3 (IFN\u2010\u03b3) exerted no inhibitory effect upon increases in CD25 or CD23 driven by CD40 ligation with sCD40L or anti\u2010CD40 antibody. These data suggest that the induction of CD25 and CD23 genes by IL\u20104 is mediated, at least in part, by an IFN\u2010\u03b3\u2010sensitive component, whereas gene activation driven via CD40 ligation involves signaling pathways which are not sensitive to IFN\u2010\u03b3.<\/jats:p>","DOI":"10.1002\/eji.1830260517","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:03:19Z","timestamp":1172800999000},"page":"1069-1073","source":"Crossref","is-referenced-by-count":15,"title":["Soluble CD40 ligand induces expression of CD25 and CD23 in resting human tonsillar B lymphocytes"],"prefix":"10.1002","volume":"26","author":[{"given":"Ellen L.","family":"Burlinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Graber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Yves","family":"Bonnefoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford W.","family":"Ozanne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Cushley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.004313"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/365340a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117677"},{"key":"e_1_2_1_5_2","first-page":"39","volume":"138","author":"Kroczek R. 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