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Since basophils from human peripheral blood can produce IL\u20104, we asked, whether soluble <jats:italic>S. mansoni<\/jats:italic> egg antigens (SEA) would trigger basophils to release IL\u20104. Basophils from healthy human donors (<jats:italic>n<\/jats:italic> = 32) without prior history of schistosomiasis were incubated with SEA in the presence of IL\u20103. In all donors, IL\u20104 was produced at different concentrations. The IL\u20104 production was dependent on the dose of SEA, was correlated with the purity of the basophil preparation, and the IL\u20104 concentration in the culture supernatant was maximal 5 h after stimulation with SEA. In addition to its IL\u20104\u2010stimulatory effect, SEA triggered basophils to degranulate, thereby releasing histamine and sulfidoleukotrienes. Stripping of receptor\u2010bound IgE from basophils inhibited both SEA\u2010 and anti\u2010IgE\u2010induced, but not ionomycin\u2010induced IL\u20104 production. Moreover, resensitization of stripped basophils with stripping supernatants or human serum restored SEA\u2010induced IL\u20104 production. This suggests that IgE is involved in the mechanism of IL\u20104 induction by SEA. Since IL\u20104 is induced in basophils from nonexposed donors, basophils may play a role as an early source of IL\u20104 in <jats:italic>S. mansoni<\/jats:italic> infection.<\/jats:p>","DOI":"10.1002\/eji.1830260528","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:03:19Z","timestamp":1172800999000},"page":"1147-1155","source":"Crossref","is-referenced-by-count":61,"title":["Human basophils release interleukin\u20104 after stimulation with <i>Schistosoma mansoni<\/i> egg antigen"],"prefix":"10.1002","volume":"26","author":[{"given":"Franco H.","family":"Falcone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens A.","family":"Dahinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard F.","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Amon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Hebestreit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Abrahamsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Klaucke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Schlaak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.10.040192.002125"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90063-Y"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001303"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.13.6065"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.4.1091"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.18.6880"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3730"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4049\/jimmunol.147.3.903","volume":"147","author":"Seder R. 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