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Engagement of CD22 with a monoclonal antibody (HB22.23) that blocks the binding of CD22 to its ligands results in rapid CD22 tyrosine phosphorylation and in increased association of CD22 with p53\/561yn kinase, p85 phosphatidyl inositol\u20103 kinase, and p72syk kinase. Synthetic peptides that span various regions of the intracellular portion of CD22 were used to map potential kinase binding sites. All three kinases associated with a tyrosine\u2010phosphorylated peptide that spans tyrosine amino acid residues 822 and 842, implicating this as an important region in mediating CD22 signal transduction. In addition, purified p56lyn directly bound to the same peptide. Engagement of CD22 with HB22.23 was sufficient to stimulate normal B cell proliferation. This study further substantiates the importance of CD22 as a B lymphocyte signaling molecule and begins to unravel the mechanisms by which CD22 cross\u2010linking can alter B cell function.<\/jats:p>","DOI":"10.1002\/eji.1830260610","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:02:32Z","timestamp":1172800952000},"page":"1246-1252","source":"Crossref","is-referenced-by-count":62,"title":["Involvement of p72syk kinase, p53\/561yn kinase and phosphatidyl inositol\u20103 kinase in signal transduction via the human B lymphocyte antigen CD22"],"prefix":"10.1002","volume":"26","author":[{"given":"Joseph M.","family":"Tuscano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Tedder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Kehrl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53140-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1994.tb03397.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34106-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90036-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10242"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.4049\/jimmunol.150.11.4719","volume":"150","author":"Engel P.","year":"1993","journal-title":"J. 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