{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:29:47Z","timestamp":1770704987967,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":3426,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>E\u2010selectin is an endothelial adhesion molecule for polymorphonuclear cells, monocytes and skin\u2010homing T cells. We have analyzed whether murine T cells are able to induce expression of E\u2010selectin <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Using models of inflammation in which T cells play either a significant or only a minor role, we compared induction of E\u2010selectin between normal mice and mice lacking functional T cells (athymic nude mice). In irritant contact dermatitis, a model without a major role for T cells, E\u2010selectin was transiently expressed within the first 24 h in both normal and nude mice. In experimental leishmaniasis (where specific T cells play an important role), a high expression of E\u2010selectin was maintained for 48 h in normal mice, whereas in nude mice expression was only transient. However, reconstitution of nude mice with 10<jats:sup>8<\/jats:sup> T cells from draining lymph nodes (LN) of <jats:italic>Leishmania<\/jats:italic>\u2010infected normal mice could restore sustained expression of E\u2010selectin. Transfer of T lymphocytes from normal LN or from LN of mice sensitized to the contact allergen trinitrochlorbenzene (TNCB) did not have this effect. T cells from TNCB\u2010sensitized mice, however, did induce sustained expression of E\u2010selectin in nude mice when TNCB was applied locally; here, reconstitution with <jats:italic>Leishmania<\/jats:italic>\u2010specific T cells had no effect. <jats:italic>In vitro<\/jats:italic>, T cells from infected or TNCB\u2010sensitized normal mice increased expression of E\u2010selectin on microvascular endothelial cells after 4 h of co\u2010culture. T cells from untreated mice were less effective. Induction was dependent on direct cell\u2010cell contact, but not on the action of interleukin\u20101\u03b1, interleukin\u20101\u03b2, tumor necrosis factor\u2010\u03b1 or interferon\u2010\u03b3. We conclude that sensitized T cells induce sustained expression of E\u2010selectin <jats:italic>in vivo<\/jats:italic> in an antigen\u2010dependent manner. This novel way of regulation could be relevant for cell\u2010mediated immunity and chronic disease. The mechanisms are unknown, but, as <jats:italic>in vitro<\/jats:italic>, might require direct cell\u2010cell contact.<\/jats:p>","DOI":"10.1002\/eji.1830260725","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:01:58Z","timestamp":1172800918000},"page":"1571-1579","source":"Crossref","is-referenced-by-count":28,"title":["Activated T cells induce expression of E\u2010selectin <i>in vitro<\/i> and in an antigen\u2010dependent manner <i>in vivo<\/i>"],"prefix":"10.1002","volume":"26","author":[{"given":"Cord","family":"Sunderk\u00f6tter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Steinbrink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Henseleit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Bosse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agatha","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Vestweber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Sorg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12476328"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.2.661"},{"key":"e_1_2_1_5_2","unstructured":"Henseleit U. 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