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T cell\u2010derived cytokines such as interleukin\u20105 and granulocyte\/macrophage colony\u2010stimulating factor inhibit eosinophil apoptosis and may therefore contribute to the development of tissue and blood eosinophilia in these disorders. Withdrawal of these cytokines leads to eosinophil apoptosis <jats:italic>in vitro<\/jats:italic>. In contrast, the mechanisms which actively induce apoptosis in eosinophils are at present not completely understood. In this study, we demonstrate that freshly isolated human eosinophils express mRNA and protein for the Fas receptor. Using anti\u2010Fas monoclonal antibody (mAb), we show that Fas activation accelerates apoptotic eosinophil death <jats:italic>in vitro<\/jats:italic>. Moreover, treatment of nasal polyps <jats:italic>ex vivo<\/jats:italic> with anti\u2010Fas mAb decreased eosinophilic tissue inflammation. However, we observed that blood as well as tissue eosinophils derived from some eosinophilic donors do not express functional Fas receptors, although Fas protein is normally expressed in these cells. This implies that the susceptibility of the Fas receptor is a matter of regulation in eosinophils as previously observed in other systems. These data suggest that Fas ligand\/Fas interactions are involved in the regulation of eosinophil apoptosis and that defects in this system could contribute to the accumulation of these cells in allergic and asthmatic diseases.<\/jats:p>","DOI":"10.1002\/eji.1830260817","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:39:17Z","timestamp":1172803157000},"page":"1775-1780","source":"Crossref","is-referenced-by-count":59,"title":["Expression and function of the Fas receptor on human blood and tissue eosinophils"],"prefix":"10.1002","volume":"26","author":[{"given":"Holger","family":"Hebestreit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shida","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Balatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Crameri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schapowal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Blaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Uwe","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90614-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50076-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(94)90119-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.4049\/jimmunol.149.11.3753","volume":"149","author":"Miyawaki T.","year":"1992","journal-title":"J. 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