{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:36:24Z","timestamp":1758814584096},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":3364,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin (IL)\u20105 is produced by both T cells and eosinophils and has been implicated in lymphocyte and eosinophil differentiation and maturation. The extent to which differences in IL\u20105 expression contribute to genetic variability in parasite immunity was investigated by comparing eosinophilia, IgE production, mastocytosis and IL\u20105 mRNA<jats:sup>+<\/jats:sup> cells following <jats:italic>Nippostrongylus brasiliensis<\/jats:italic> infection of resistant (BALB\/c) and susceptible (C57BL\/6) mice. In uninfected mice, IL\u20105 mRNA<jats:sup>+<\/jats:sup> cells detected by <jats:italic>in situ<\/jats:italic> hybridization were distributed throughout the lamina propria and crypt regions of the small intestine in both strains, but were 1.5\u2010fold higher in BALB\/c than in C57BL\/6 mice. Following <jats:italic>N. brasiliensis<\/jats:italic> infection, the numbers of IL\u20105 mRNA<jats:sup>+<\/jats:sup> cells in BALB\/c mice continued to increase until day 11 post\u2010infection at which time they were more than 4\u2010fold more numerous than in uninfected control mice of the same strain. In C57BL\/6 mice, IL\u20105 mRNA<jats:sup>+<\/jats:sup> cells reached peak numbers on day 7 post\u2010infection, only 1.5\u2010fold higher than uninfected controls, but the numbers began to decline thereafter. At all time points after day 5, the numbers of IL\u20105 mRNA<jats:sup>+<\/jats:sup> cells in the gut of C57BL\/6 mice were significantly lower than BALB\/c mice. The differences in numbers of IL\u20105 mRNA<jats:sup>+<\/jats:sup> cells induced by infection in each strain of mice correlated with changes in blood and intestinal eosinophilia, mastocytosis and IgE production and was reflected in differences in worm expulsion and egg counts. Although numbers of intestinal IgA\u2010containing cells increased in both strains after infection, there was no difference between strains except at day 11 when there were significantly higher numbers in BALB\/c mice than in C57BL\/6 mice. These results suggest that IL\u20105 is an important regulatory factor determining host immunity to parasite infection and that differential regulation of IL\u20105 expression explains in part the observed strain differences with respect to parasite resistance.<\/jats:p>","DOI":"10.1002\/eji.1830260926","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:34:16Z","timestamp":1172802856000},"page":"2133-2139","source":"Crossref","is-referenced-by-count":19,"title":["Differential expression of interleukin\u20105 mRNA<sup>+<\/sup> cells and eosinophils in <i>Nippostrongylus brasiliensis<\/i> infection in resistant and susceptible strains of mice"],"prefix":"10.1002","volume":"26","author":[{"given":"Yafen","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shisan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence L. 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