{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:56:59Z","timestamp":1770713819534,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":3364,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice rendered B cell deficient by targeted disruption of the immunoglobulin \u03bc chain gene (IgM\u2212\/\u2212 mice) were used to analyze the role of antibodies and B cells in viral infections; homozygous IgM\u2212\/\u2212 mice were bred in a way to avoid transmission of maternal antibodies. After infection with vesicular stomatitis virus (VSV), IgM\u2212\/\u2212 mice developed paralytic disease and subsequently died, whereas C57BL\/6 control mice or IgM\u2212\/\u2212 mice passively protected with VSV\u2010neutralizing antibodies survived. Furthermore, IgM\u2212\/\u2212 mice showed increased natural killer (NK) activity upon exposure to either lymphocytic choriomeningitis virus (LCMV) or to poly(I) \u00b7 poly(C), while NK activity in untreated IgM\u2212\/\u2212 mice was within normal ranges. Cytotoxic T cell responses were comparable in IgM\u2212\/\u2212 and control mice infected either with VSV or with vaccinia virus or with low doses of LCMV (10<jats:sup>2<\/jats:sup> infectious focus\u2010forming units [ifu]). After intracerebral infection with LCMV\u2010Armstrong, CD8<jats:sup>+<\/jats:sup> T cell\u2010mediated lethal lymphocytic choriomeningitis developed independently of the presence of B cells and antibodies. After infection with high doses (2 \u00d7 10<jats:sup>6<\/jats:sup> \u2212 5 \u00d7 10<jats:sup>6<\/jats:sup> ifu) of LCMV\u2010WE or LCMV\u2010Docile, IgM\u2212\/\u2212 mice exhibited a reduced capacity to control these primary infections and had elevated virus liters for prolonged times (&gt;60 days). Nevertheless, the cytotoxic T cell response against LCMV in the early phase of infection was comparable in IgM\u2212\/\u2212 and control mice, but disappeared in those IgM\u2212\/\u2212 mice which had a persistent viral infection. Cytotoxic T cell memory was apparently unimpaired in low\u2010dose\u2010primed IgM\u2212\/\u2212mice, which were able to control the primary virus infection; both IgM\u2212\/\u2212 and control mice cleared a high intravenous dose of virus within 2 days after challenge infection. This indicates that an efficient T cell memory against LCMV was established in the absence of B cells.<\/jats:p>","DOI":"10.1002\/eji.1830260943","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:34:16Z","timestamp":1172802856000},"page":"2257-2262","source":"Crossref","is-referenced-by-count":73,"title":["Immunity to viruses in B cell\u2010deficient mice: Influence of antibodies on virus persistence and on T cell memory"],"prefix":"10.1002","volume":"26","author":[{"given":"Marie\u2010Anne","family":"Br\u00fcndler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Aichele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Rajewsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"10","volume-title":"Pathogenesis of infectious disease","author":"Mims C. 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