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CD40 ligation protected cells from apoptosis induced by calcium ionophore through an initial, rapid and apparently Bcl\u20102\u2010independent mechanism, associated with up\u2010regulation of Bcl\u2010x<jats:sub>L<\/jats:sub>. However, rescue from apoptosis induced by inhibition of macromolecular synthesis required several hours of prior stimulation with CD40 ligand\/antibody and was accompanied by up\u2010regulation of Bcl\u20102. In contrast, IL\u20104 did not up\u2010regulate Bcl\u20102 or Bcl\u2010x<jats:sub>L<\/jats:sub> and did not inhibit apoptosis induced by inhibitors of macromolecular synthesis. However, IL\u20104 did protect Ramos cells from apoptosis induced by calcium ionophore and this effect was accompanied by inhibition of ionophore\u2010induced expression of an immediate early gene encoding a 36\u2010kDa zinc\u2010finger protein, <jats:italic>Berg36<\/jats:italic>. Anti\u2010sense blockade of <jats:italic>Berg36<\/jats:italic> expression partially inhibited ionophore\u2010induced apoptosis to an extent commensurate with the level of IL\u20104 protection, implicating <jats:italic>Berg36<\/jats:italic> function as a requirement for apoptosis induced through calcium signaling and as a target for IL\u20104 through which this cytokine inhibits apoptosis in Ramos B cells. These distinct mechanisms for rescue from apoptosis by CD40 and IL\u20104 may help explain the co\u2010operative roles of these T cell\u2010derived signals for B cell survival.<\/jats:p>","DOI":"10.1002\/eji.1830261013","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:33:12Z","timestamp":1172799192000},"page":"2356-2363","source":"Crossref","is-referenced-by-count":29,"title":["Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin\u20104 receptor: role for inhibition of an early response gene, <i>Berg36<\/i>"],"prefix":"10.1002","volume":"26","author":[{"given":"Zhi\u2010Qiang","family":"Ning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Norton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.12.1243"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210504"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(92)90200-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221217"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/364645a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.4049\/jimmunol.152.6.2821","volume":"152","author":"Parry S. 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