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Mice homozygous for the lpr mutation and carrying T cell receptor (TCR) \u03b1\u03b2 transgenes specific for the LCMV glycoprotein peptide aa 33\u201341 in the context of H\u20102D<jats:sup>b<\/jats:sup> were used. Five main results emerged: first, development of lymphadenopathy and of CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup> double\u2010negative B220<jats:sup>+<\/jats:sup> T cells in lpr mice was not inhibited by the \u03b1\u03b2 TCR transgenes; second, tolerance induction and peripheral deletion of CD8<jats:sup>+<\/jats:sup> T cells induced by LCMV glycoprotein peptide injection was independent of Fas expression; third, clonal down\u2010regulation of Fas\u2010deficient TCR\u2010transgenic CD8<jats:sup>+<\/jats:sup> T cells after acute LCM virus infection was identical to the decline of transgenic T cells expressing Fas; fourth, <jats:italic>in vivo<\/jats:italic> activated CD8<jats:sup>+<\/jats:sup> effector T cells from TCR transgenic and TCR\u2010lpr\/lpr mice were equally susceptible to activation\u2010induced cell death <jats:italic>in vitro<\/jats:italic>; and fifth, transgenic effector T cells from lpr\/lpr mice were cleared in the declining phase of the immune response <jats:italic>in vivo<\/jats:italic> without giving rise to CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup> double\u2010negative T cells. Taken together, these data suggest that the homeostatic regulation of CD8<jats:sup>+<\/jats:sup> T cells after antigen challenge <jats:italic>in vivo<\/jats:italic> is regulated by mechanisms that do not require Fas.<\/jats:p>","DOI":"10.1002\/eji.1830261215","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:29:25Z","timestamp":1172798965000},"page":"2903-2910","source":"Crossref","is-referenced-by-count":48,"title":["Homeostatic regulation of CD8<sup>+<\/sup> T cells after antigen challenge in the absence of Fas (CD95)"],"prefix":"10.1002","volume":"26","author":[{"given":"Christine","family":"Zimmermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Rawiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudine","family":"Blaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7533326"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1994.tb00889.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4049\/jimmunol.148.4.1274","volume":"148","author":"Watanabe\u2010Fukunaga R.","year":"1992","journal-title":"J. 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