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In contrast to the action of I\u2010E expression on its own, which has mainly a suppressive effect post\u2010triggering, the combination of I\u2010A<jats:sup>b<\/jats:sup> and I\u2010E had a marked protective effect. Assuming, on the basis of previous experience with the I\u2010A<jats:sup>b<\/jats:sup> allele, that it might act through suppressing early IL\u20104 production, we treated mice with the 11B11 IL\u20104\u2010neutralizing antibody around the time of initial immunization with collagen. Treatment over a period extending to 6 days post\u2010immunization exacerbated the arthritis, but when curtailed to 2 days post\u2010immunization (and tested in pristane\u2010primed animals), the disease was reduced. We conclude that IL\u20104 plays an essential role in triggering the disease.<\/jats:p>","DOI":"10.1002\/eji.1830261259","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:29:25Z","timestamp":1172798965000},"page":"3234-3237","source":"Crossref","is-referenced-by-count":27,"title":["Protective major histocompatibility complex genes and the role of interleukin\u20104 in collagen\u2010induced arthritis"],"prefix":"10.1002","volume":"26","author":[{"given":"Matthias","family":"Hesse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015einasi","family":"Bayrak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avrion","family":"Mitchison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.18.8562"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.397"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.001305"},{"key":"e_1_2_1_5_2","unstructured":"Yin Z. 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