{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:49:12Z","timestamp":1758818952072},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":3256,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanism leading to selective production and accumulation of eosinophils in certain allergic skin diseases is unknown. Cyclophosphamide treatment (150 mg\/kg) of BALB\/c mice 48 h before sensitization with picryl chloride (PCI) resulted in striking blood and tissue eosinophilia, maximal at 13 days. Blood eosinophilia was not induced by the sensitization with oxazolone and 2, 4\u2010dinitrofluorobenzene. Challenge with 1% PCI, but not croton oil caused preferential eosinophil accumulation into the dermis, which was associated with the enhanced expression of vascular cell adhesion molecule 1 (VCAM\u20101) on endothelial cells. Intraveneous administration of anti\u2010VCAM\u20101 monoclonal antibody abrogated eosinophil infiltration. In this murine model, we examined the role of several cytokines, including chemokines in inducing selective tissue eosinophilia <jats:italic>in vivo.<\/jats:italic> Local administration of antibodies against interleukin (IL)\u20101\u03b2, IL\u20104, tumor necrosis factor (TNF)\u2010\u03b1, and RANTES, but not against IL\u20105 before challenge inhibited hapten\u2010induced eosinophil recruitment. Intradermal injection of recombinant (r)IL\u20101\u03b2, rIL\u20104, rTNF\u2010\u03b1, rRANTES, and rMIP\u20101\u03b1 induced marked eosinophil accumulation. Nonetheless, intradermal rIL\u20105 was not a chemoattractant for eosinophils <jats:italic>in vivo.<\/jats:italic> Our findings suggest that IL\u20101\u03b2, IL\u20104, TNF\u2010\u03b1, and RANTES contribute to the selective accumulation of eosinophils in contact sensitivity reaction. Although circulating IL\u20105 can activate eosinophils and prolong their survival, locally secreted IL\u20105 is not crucial for inducing eosinophil recruitment into the skin.<\/jats:p>","DOI":"10.1002\/eji.1830270113","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T03:31:13Z","timestamp":1172806273000},"page":"85-91","source":"Crossref","is-referenced-by-count":18,"title":["Cyclophosphamide\u2010induced blood and tissue eosinophilia in contact sensitivity: Mechanism of hapten\u2010induced eosinophil recruitment into the skin"],"prefix":"10.1002","volume":"27","author":[{"given":"Takahiro","family":"Satoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qui\u2010Ji","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Yokozeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115278"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.4049\/jimmunol.146.10.3419","volume":"146","author":"Walsh G. 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