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It is still controversial in which anatomical site activation\u2010induced apoptosis and elimination of T cells occur. To address this question, we used mice transgenic for a T cell receptor (F5) specific for an influenza virus nucleoprotein peptide (NP68) presented on the major histocompatibility complex H\u20102 D<jats:sup>b<\/jats:sup> molecule. Accumulation and apoptosis of T cells was studied using terminal deoxynucleotidyl transferase\u2010mediated dUTP\u2010biotin nick end\u2010labeling <jats:italic>in situ<\/jats:italic> combined with immunohistology after intraperitoneal injection of the cognate peptide into F5 mice which are wild type or deficient for Rag\u20101. After 4 days of peptide treatment, large perivascular infiltrations of CD8<jats:sup>+<\/jats:sup> cells were observed in liver, lung, and kidney of F5 mice. CD8<jats:sup>+<\/jats:sup> cell numbers were also increased in skin and small intestine, but not in brain or heart muscle of peptide\u2010treated animals. The infiltrating CD8<jats:sup>+<\/jats:sup> cells show an increased percentage of apoptosis in liver, lung and, most strikingly, the kidney. These data suggest that in the F5 system, T cell disposal after activation occurs in a number of organs. Essentially identical findings were obtained in Rag\u20101<jats:sup>+\/+<\/jats:sup> and Rag\u20101<jats:sup>\u2010\/\u2010<\/jats:sup> F5 mice, suggesting that the deletion mechanism did not involve other T or B cells.<\/jats:p>","DOI":"10.1002\/eji.1830270302","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T04:32:52Z","timestamp":1172809972000},"page":"577-583","source":"Crossref","is-referenced-by-count":25,"title":["Multiple sites of post\u2010activation CD8<sup>+<\/sup> T cell disposal"],"prefix":"10.1002","volume":"27","author":[{"given":"Andreas","family":"Wack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Corbella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Harker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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