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To address this difference, we developed panels of schistosomal egg antigen (SEA)\u2010specific T cell hybridomas to compare the responses of C3H and C57BL\/6 mice to the major egg antigen p40. All derived C3H T cell hybridomas, despite being clonally distinct and restricted by either I\u2010A<jats:sup>k<\/jats:sup> or I\u2010E<jats:sup>k<\/jats:sup>, responded to recombinant fragment 15\u20101 of the p40 antigen, while none of the C57BL\/6 T cell hybridomas did. Consistent with the observed monoclonal T cell responses, polyclonal lymph node cells from schistosome\u2010infected C3H mice reacted strongly to fragment 15\u20101, which contrasted sharply with the weak response displayed by the C57BL\/6 strain. Moreover, studies with congenic mice demonstrated that the strong CD4<jats:sup>+<\/jats:sup> T cell response to fragment 15\u20101 was under major histocompatibility complex control and segregated with the H\u20102<jats:sup>k<\/jats:sup> haplotype. These findings suggest that a dominant T cell response against a major egg antigen may represent a risk factor for the development of severe disease.<\/jats:p>","DOI":"10.1002\/eji.1830270314","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T04:32:52Z","timestamp":1172809972000},"page":"666-670","source":"Crossref","is-referenced-by-count":29,"title":["Differential antigen recognition by T cell populations from strains of mice developing polar forms of granulomatous inflammation in response to eggs of <i>Schistosoma mansoni<\/i>"],"prefix":"10.1002","volume":"27","author":[{"given":"Hector J.","family":"Hernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy C.","family":"Trzyna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Cordingley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Brodeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel J.","family":"Stadecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"527","volume-title":"Annu. 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