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We could thus compare normal or B cell\u2010deficient mice born from Ig\u2010deprived (Ig<jats:sup>\u2212<\/jats:sup>) or phenotypically normal mothers (Ig<jats:sup>+<\/jats:sup>). B cell\u2010deficient progeny of heterozygous mothers contain no detectable serum IgA or IgM, but IgG concentrations that peak at 2 mg\/ml by 7\u201321 days of age, decay after weaning with a half\u2010life of 7 days, and remain detectable for 2 months after birth. At 7 days after birth, \u03bcMT\/+ progeny born of Ig<jats:sup>+<\/jats:sup> mothers contain two\u2010 to threefold higher numbers of bone marrow (BM) pre\u2010B and B cells, and of splenic B cells, compared to mice of the same age born from Ig<jats:sup>\u2212<\/jats:sup> mothers. In contrast, the former progeny exhibit two to four times lower numbers of Ig\u2010secreting plasma cells in spleen and thymus, and contain sixfold lower serum IgM concentrations. A similar maternal IgG\u2010dependent stimulation of BM B cell precursors is also observed in \u03bcMT\/\u03bcMT progeny. No significant differences were detected between the groups on day 3 after birth, suggesting the requirement for a minimal IgG concentration in the serum.<\/jats:p>","DOI":"10.1002\/eji.1830270330","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T04:32:52Z","timestamp":1172809972000},"page":"788-793","source":"Crossref","is-referenced-by-count":21,"title":["Maternal IgG stimulates B lineage cell development in the progeny"],"prefix":"10.1002","volume":"27","author":[{"given":"Evelyne","family":"Malanch\u00e8re","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Huetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(83)90236-X"},{"key":"e_1_2_1_3_2","first-page":"57","volume-title":"Fc Receptors and the Action of Antibodies","author":"Simister N. 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