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Whereas no virus\u2010specific CTL were detected in the CNS of susceptible B10.Q and B10.S mice 7 days post\u2010infection, D\u2010restricted CTL were identified readily in the CNS of resistant B10 animals. There was no evidence of K\u2010restricted CTL in the CNS of B10 mice at day 7 post\u2010infection. The presence of both K\u2010 and D\u2010restricted virus\u2010specific CTL in the spleen of immunized B10 mice demonstrates that the exclusive use of D molecules by CTL in the CNS of mice 7 days post\u2010infection is not due to the inability of the K molecules to present viral peptides to lymphocytes. We conclude that the prominent role of the <jats:italic>D<\/jats:italic> locus in determining resistance or susceptibility to TMEV\u2010induced demyelination is determined by factors governing the regulation of the immune response, and not by the presence or absence of CTL precursors capable of recognizing viral peptides presented by the K and D antigen\u2010presenting molecules, or by differences in the ability of the K and D molecules to present viral peptides.<\/jats:p>","DOI":"10.1002\/eji.1830270424","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T04:32:40Z","timestamp":1172809960000},"page":"963-970","source":"Crossref","is-referenced-by-count":29,"title":["Differential generation of class I H\u20102D\u2010 versus H\u20102K\u2010restricted cytotoxicity against a demyelinating virus following central nervous system infection"],"prefix":"10.1002","volume":"27","author":[{"given":"Xiaoqi","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry R.","family":"Pease","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.145.3.644"},{"key":"e_1_2_1_3_2","first-page":"353","volume":"10","author":"Ruby J.","year":"1991","journal-title":"Lymphokine Cytokine Res."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(88)90471-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.9951"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.002155"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.4005"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.4049\/jimmunol.148.3.953","volume":"148","author":"Pullen J. 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