{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:04:37Z","timestamp":1787501077912,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":3171,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 4 kb human interleukin\u201013 receptor (IL\u201013R) chain cDNA was cloned from a B cell cDNA library using expressed sequence tags homologous to mouse IL\u201013R as probes. The deduced protein sequence shows a significant level of sequence identity with the IL\u20105R and the human IL\u201013R identified recently by expression cloning. The cytoplasmic region is very highly conserved between human and mouse homologs and contains a consensus binding motif for a signal transducer and activator of transcription. The cDNA encodes a protein binding IL\u201013 when expressed alone which participates in a receptor complex for both IL\u20104 and IL\u201013 when expressed in conjunction with the IL\u20104R\u03b1 chain. Transcripts for this IL\u201013R chain could be detected in most tissues and organs studied and in T, B, endothelial cells, basophilic, immature mast cell, and monocytic cell lines. The pattern of expression is different from the other recently cloned IL\u201013R molecule, and correlates with sites where IL\u20104 and IL\u201013 signaling is known to occur. This novel receptor is therefore likely to be implicated in reactions involved in IgE responses, T helper 2 differentiation, adhesion of leukocytes to endothelium, and therefore in pathological phenomena such as allergy, atopy, and asthma.<\/jats:p>","DOI":"10.1002\/eji.1830270425","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:32:40Z","timestamp":1172791960000},"page":"971-978","source":"Crossref","is-referenced-by-count":78,"title":["A novel 4\u2010kb interleukin\u201013 receptor \u03b1 mRNA expressed in human B, T, and endothelial cells encoding an alternate type\u2010II interleukin\u20104\/ interleukin\u201013 receptor"],"prefix":"10.1002","volume":"27","author":[{"given":"Jean\u2010Fran\u00e7ois","family":"Gauchat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Schlagenhauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning\u2010Ping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat","family":"Yamage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Jeannin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Alouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Elson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi D.","family":"Notarangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Pietro","family":"Eugster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Bonnefoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/362248a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05927.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.3.853"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.18.6880"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220505"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3730"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.2.636"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.6.2385"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.2.463"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260504"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90063-K"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.4049\/jimmunol.154.2.799","volume":"154","author":"Bochner B. S.","year":"1995","journal-title":"J. Immunol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1182\/blood.V84.6.1913.1913","volume":"84","author":"Sironi M.","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1182\/blood.V87.10.4286.bloodjournal87104286","volume":"87","author":"Schnyder B.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90661-W"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.4049\/jimmunol.149.4.1432","volume":"149","author":"Moser R.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(94)90005-1"},{"key":"e_1_2_1_20_2","first-page":"567","volume":"122","author":"Moser R.","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.4032"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/377173a0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.12286"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.7681"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1182\/blood.V86.11.4218.bloodjournal86114218","volume":"86","author":"Wang L. M.","year":"1995","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7694370"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06388.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8085155"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80439-2"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/380627a0"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/380630a0"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.23.13869"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00512-8"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.15.8797"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266076"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266077"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90141-8"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.1.38.bloodjournal85138"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.619"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)80600-1"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.497"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.28.16921"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.18.6934"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.2.389"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.5.1775"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250335"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/377065a0"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)54067-8"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.1.466"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/2.7.669"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)55027-3"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190618"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90515-1"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7871433"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.46.29265"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830270425","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830270425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T17:41:10Z","timestamp":1698428470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830270425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1002\/eji.1830270425"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830270425","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}