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To address the question of whether cross\u2010linking of CD4\/HIV gp120 complexes by antibodies were sufficient to induce T cell depletion <jats:italic>in vivo<\/jats:italic>, we developed an animal model of continuous interaction between human CD4 (hCD4), gp120 and anti\u2010gp120 antibodies in the absence of other viral factors. Double\u2010transgenic mice have been generated in which T cells express on their membrane hCD4 and secrete HIV gp120. Although these mice have hCD4\/gp120 complexes present on the surface of T cells, they do not show gross immunological abnormalities, and they are able to produce anti\u2010gp120 antibodies following immunization with denaturated gp120. However, double\u2010transgenic mice with antibodies to gp120, when immunized with tetanus toxoid, mount an IgG response that is significantly lower than that of double\u2010transgenic mice without antibodies to gp120. Furthermore, the presence of anti\u2010gp120 antibodies leads to CD4<jats:sup>+<\/jats:sup> T cell depletion and immunodeficiency in the absence of HIV infection. Thus, the antibody response to gp120 can lead to CD4<jats:sup>+<\/jats:sup> T cell attrition <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830270604","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T05:00:39Z","timestamp":1172811639000},"page":"1319-1324","source":"Crossref","is-referenced-by-count":22,"title":["Induction of CD4<sup>+<\/sup> T cell depletion in mice doubly transgenic for HIV gp120 and human CD4"],"prefix":"10.1002","volume":"27","author":[{"given":"Oretta","family":"Finco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Nuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"de Magistris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Mangiavacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Aiuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Forte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Fantoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman Van Der","family":"Putten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Abrignani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3277274"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.57.1.183-289.1993"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302043280508"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90086-M"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8098552"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7902613"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.2.331"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1352911"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.11.3392.3392"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/347286a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.4.1099"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.4049\/jimmunol.154.10.5555","volume":"154","author":"Muro\u2010Cacho C. 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