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In chimeras reconstituted with mixtures of bone marrow (BM) cells from normal and B cell\u2010deficient donors, we show that the rate of BM B cell production is a constant function of the number of BM pre\u2010B cells and is not modified by the peripheral B cell pool size, <jats:italic>i.e.<\/jats:italic> there is no feedback regulation of the central pre\u2010B cell compartment by the number of mature B cells. We also show that the physiological number of peripheral B cells requires a minimum continuous input of newly formed cells, but is not determined by the number of B cell precursors. Chimeras with a threefold reduced rate of BM B cell production have normal numbers of peripheral B cells. Parabiosis between normal and B cell\u2010deficient mice showed that the BM B cell production of one mouse suffices to replenish the B cell pool of three mice. Finally, we show that the compartment of activated IgM\u2010secreting B cells is homeostatically autonomous since the number of cells it comprises is regulated independently of the size of the mature B cell pool. The results presented here support a model of the immune system in which the size of the different B cell compartments, <jats:italic>i.e.<\/jats:italic> pre\u2010B, resting B and IgM\u2010secreting, is autonomously regulated.<\/jats:p>","DOI":"10.1002\/eji.1830270731","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T05:21:40Z","timestamp":1172812900000},"page":"1801-1807","source":"Crossref","is-referenced-by-count":57,"title":["Independent homeostatic regulation of B cell compartments"],"prefix":"10.1002","volume":"27","author":[{"given":"Fabien","family":"Agen\u00e8s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Manuela","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio A.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-294"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.2.626"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.19.8661"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80065-M"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5238.985"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90180-9"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.532"},{"key":"e_1_2_1_9_2","volume-title":"An introduction to cell population kinetics","author":"Aherne W. 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