{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:41Z","timestamp":1791405221284,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":3050,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypersensitivity to nickel (Ni) represents the most common manifestation of contact allergy in humans. The role of metal\u2010specific T cells in this disease is well established, but the molecular interactions involved in their activation are poorly understood. We examined the T cell receptor (TCR) repertoire in T cells activated with either NiSO<jats:sub>4<\/jats:sub> or NiSO<jats:sub>4<\/jats:sub>\u2010treated human serum albumin from six allergic patients. For the three most hyperreactive donors, we found a strong over\u2010represention of the TCR BV17 element. TCR sequencing for one of these donors revealed an additional skewing for AV1 as well as a selection for an N region encoded argine at position 95 of the BV17 complementarity determining region (CDR)3. Since Arg is not known to participate in Ni complexing, we suppose that this selection is driven by contacts with peptide rather than nickel. However, the CDR1 of BV17 contains a unique combination of amino acids (HDA) that bears similarities to known motifs in Ni\u2010binding proteins or peptides. We therefore propose that the severe hypersensitivity reactions found in BV17 over\u2010expressors may be the result of Ni<jats:sup>2+<\/jats:sup> ions bridging the germ\u2010line\u2010encoded BV17 CDR1 loop to corresponding sites in the major histocompatibility complex\/peptide complex and thereby creating a superantigen\u2010like enhancement of weak TCR\u2010peptide contacts.<\/jats:p>","DOI":"10.1002\/eji.1830270808","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T05:38:11Z","timestamp":1172813891000},"page":"1865-1874","source":"Crossref","is-referenced-by-count":61,"title":["Dominance of the BV17 element in nickel\u2010specific human T cell receptors relates to severity of contact sensitivity"],"prefix":"10.1002","volume":"27","author":[{"given":"J\u00f6rg","family":"Vollmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dormoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Ulrich","family":"Weltzien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Moulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03318.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.4049\/jimmunol.135.6.3929","volume":"135","author":"Sinigaglia F.","year":"1985","journal-title":"J. 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