{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T09:43:18Z","timestamp":1698486198656},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":2987,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An inflammatory response was induced in C57BL\/6 mice using silver nitrate. Co\u2010administration of a recombinant mouse interleukin\u20101 receptor antagonist (rmIL\u20101ra) significantly reduced the magnitude of hepatic induction of the mRNA specifying the serum amyloid A (A\u2010SAA) isoforms A\u2010SAA1 and A\u2010SAA2 for up to 24 h. In relative terms, the amount by which the induction of serum A\u2010SAA protein levels could be countered by the antagonist was less, probably reflecting extrahepatic A\u2010SAA synthesis that is regulated independently of IL\u20101. Induction of hepatic serum amyloid P component (SAP) mRNA and other acute\u2010phase reactant (APR) mRNA were all partially blocked by rmIL\u20101ra for up to 24 h, indicating that induction of these APR mRNA involves both IL\u20101 and additional factors acting independently of IL\u20101. Hepatic mRNA levels of the negative APR apolipoprotein A\u2010I (apo A\u2010I) and serum albumin were down\u2010regulated by silver nitrate treatment; rmIL\u20101ra partially restored serum albumin mRNA levels but not those of apo A\u2010I. The IL\u20101ra\u2010mediated reduction in inflammation\u2010induced hepatic mRNA and serum protein concentrations of A\u2010SAA and SAP (the precursors of the main protein components of amyloid deposits in secondary amyloidosis) was, however, not sufficient to prevent or delay early amyloid deposition in the silver nitrate\/amyloid enhancing factor model of accelerated amyloidosis. The rmIL\u20101ra may be a useful component in future therapies to control inflammation and secondary amyloidosis; in addition, it will be a useful tool for the detailed analysis of the IL\u20101\u2010driven aspects of inflammation <jats:italic>per se<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830271019","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T04:08:42Z","timestamp":1172808522000},"page":"2593-2599","source":"Crossref","is-referenced-by-count":1,"title":["Down\u2010regulation of the major circulating precursors of proteins deposited in secondary amyloidosis by a recombinant mouse interleukin\u20101 receptor antagonist"],"prefix":"10.1002","volume":"27","author":[{"given":"Sharon","family":"Grehan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Herbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander S.","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"381","volume":"49","author":"Kisilevsky R.","year":"1983","journal-title":"Lab. 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