{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:26:58Z","timestamp":1791224818309,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":2957,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The majority of peripheral blood \u03b3\u03b4 T cells in human adults expresses T cell receptors (TCR) with identical V regions (V\u03b39 and V\u03b42). These V\u03b39V\u03b42 T cells recognize the major histocompatibility complex (MHC) class I\u2010deficient B cell line Daudi and broadly distributed nonpeptidic antigens present in bacteria and parasites. Here we show that unlike \u03b1\u03b2 or V\u03b39\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u03b3\u03b4 T cells, the majority of V\u03b39V\u03b42T cells harbor natural killer inhibitory receptors (KIR) (mainly CD94\/NKG2A heterodimers), which are known to deliver inhibitory signals upon interaction with MHC class I molecules. Within V\u03b39\u03b42 T cells, KIR were mainly expressed by clones exhibiting a strong lytic activity against Daudi cells. In stark contrast, almost all V\u03b39V\u03b42 T cell clones devoid of killing activity were KIR\n                    <jats:sup>\u2212<\/jats:sup>\n                    , thus suggesting a coordinate acquisition of KIR and cytotoxic activity within V\u03b39V\u03b42 T cells. In functional terms, KIR inhibited lysis of MHC class I\u2010positive tumor B cell lines by V\u03b39V\u03b42 cytotoxic T lymphocytes (CTL) and raised their threshold of activation by microbial antigens presented by MHC class I\u2010positive cells. Furthermore, masking KIR or MHC class I molecules revealed a TCR\u2010dependent recognition by V\u03b39V\u03b42 CTL of ligands expressed by activated T lymphocytes, including the effector cells themselves. Taken together, these results suggest a general implication of V\u03b39V\u03b42 T cells in immune response regulation and a central role of KIR in the control of self\u2010reactive \u03b3\u03b4 CTL.\n                  <\/jats:p>","DOI":"10.1002\/eji.1830271111","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:06:15Z","timestamp":1172790375000},"page":"2812-2821","source":"Crossref","is-referenced-by-count":128,"title":["Control of self\u2010reactive cytotoxic T lymphocytes expressing \u03b3\u03b4 T cell receptors by natural killer inhibitory receptors"],"prefix":"10.1002","volume":"27","author":[{"given":"Franck","family":"Halary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Alix","family":"Peyrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Champagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Lopez\u2010Botet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Moretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Moretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Vi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Fourni\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bonneville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60664-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(90)90097-S"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.619"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.597"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1589"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.2.537"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.4.1453"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.505"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7716543"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90025-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.4049\/jimmunol.144.8.3238","volume":"44","author":"Aramburu J.","year":"1990","journal-title":"J. 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