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From this library we identified a cDNA for a serine protease inhibitor, a serpin, which is absent from monocytes, B cells and T cells but expressed in CD40\u2010activated monocyte\u2010 and progenitor cell\u2010generated dendritic cells. In addition, the serpin is expressed in a lung fibroblast cell line and keratinocytes. Its mRNA is detected only in tonsil and thymus. The serpin described here reportedly functions as a megakaryocyte maturation factor in the presence of interleukin (IL)\u20103 and IL\u201011. This suggests that dendritic cells may promote the immune response by protecting IL\u20103 and IL\u201011 or other essential proteins from degradation.<\/jats:p>","DOI":"10.1002\/eji.1830271208","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T03:59:58Z","timestamp":1172807998000},"page":"3130-3134","source":"Crossref","is-referenced-by-count":11,"title":["Polymerase chain reaction\u2010based identification of a novel serpin from human dendritic cells"],"prefix":"10.1002","volume":"27","author":[{"given":"Chris G. 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