{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:48:38Z","timestamp":1762458518630},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":2926,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homozygous (\u0394ccr5\/\u0394ccr5) and heterozygous (CCR5\/\u0394ccr5) deletions in the \u03b2\u2010chemokine receptor 5 (CCR5) gene, which encodes for the major co\u2010receptor for macrophage\u2010tropic HIV\u20101 entry, have been implicated in resistance to HIV infection and in protection against disease progression, respectively. The CCR5\/\u0394ccr5 genotype was found more frequently in long\u2010term nonprogressors (LTNP) (31.0%) than in progressors (10.6%, <jats:italic>p<\/jats:italic> &lt; 0.0001), in agreement with previous studies. Kaplan\u2010Meier survival analyses showed that a slower progression of disease, <jats:italic>i.e.<\/jats:italic> higher proportion of subjects with CD4<jats:sup>+<\/jats:sup> T cell counts &gt;500\/\u03bcl (<jats:italic>p<\/jats:italic> = 0.0006) and a trend toward a slower progression to AIDS (<jats:italic>p<\/jats:italic> = 0.077), was associated with the CCR5\/\u0394ccr5 genotype. However, when LTNP were analyzed separetely, no significant differences in CD4<jats:sup>+<\/jats:sup> T cell counts (<jats:italic>p<\/jats:italic> = 0.12) and viremia levels (<jats:italic>p<\/jats:italic> = 0.65) were observed between the wild\u2010type (69 % of LTNP) and the heterozygous (31.0 %) genotypes. Therefore, there are other factors which play a major role in determining the status of nonprogression in the majority of LTNP. Furthermore, there was no evidence that the CCR5\/\u0394ccr5 genotype was associated with different rates of disease progression in the group of progressors. Taken together, these results indicate that the CCR5\/\u0394ccr5 genotype is neither essential nor sufficient for protection against the progression of HIV disease.<\/jats:p>","DOI":"10.1002\/eji.1830271220","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T03:59:58Z","timestamp":1172807998000},"page":"3223-3227","source":"Crossref","is-referenced-by-count":29,"title":["Genetic polymorphism of CCR5 gene and HIV disease: The heterozygous (CCR5\/\u0394ccr5) genotype is neither essential nor sufficient for protection against disease progression"],"prefix":"10.1002","volume":"27","author":[{"given":"Renate A.","family":"Morawetz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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