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We show here that cytotoxic T lymphocytes of the V\u03b39\/V\u03b42 subset, but not of the V\u03b41 subset of human \u03b3\u03b4 T cells, express natural killer inhibitory receptors (KIR) with specificity for different HLA class I alleles that down\u2010regulate TCR\u2010mediated signaling in response to HLA class I\u2010expressing B cell lymphomas. V\u03b39\/V\u03b42 T cell clones with a T helper cell phenotype lack KIR and produce lymphokines in response to most human B cell lymphomas, just as they do upon recognition of the HLA class l\u2010deficient human Burkitt's lymphoma Daudi. Thus, human V\u03b39\/V\u03b42 T cells have an innate specificity for nonpolymorphic cell surface structures expressed by many lymphoma cells and their cytotoxic activity is controlled by KIR. These results imply a general role of human V\u03b39\/V\u03b42 T cells in the defense against hematopoietic tumors that is distinct from NK cells.<\/jats:p>","DOI":"10.1002\/eji.1830271236","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T03:59:58Z","timestamp":1172807998000},"page":"3368-3379","source":"Crossref","is-referenced-by-count":92,"title":["Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human V\u03b39\/V\u03b42 T cells in tumor immunity"],"prefix":"10.1002","volume":"27","author":[{"given":"Paul","family":"Fisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Meuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Rothenfu\u00dfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriane","family":"Viale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Kock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soldano","family":"Ferrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Fradelizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Moretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Georg","family":"Rammensee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Coulie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"van der Bruggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.003225"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/365053a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2272"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.5.1597"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8146660"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250737"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/375155a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.5.1567"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.4049\/jimmunol.145.10.3202","article-title":"Human V\u03b39\/V\u03b42 T cell receptor\u2010\u03b3\u03b4 lymphocytes show specificity to Daudi Burkitt's lymphoma cells","volume":"145","author":"Sturm E.","year":"1990","journal-title":"J. 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