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In addition, following up\u2010regulation of the Fas (CD95) surface receptor by CD40 ligation, these cells also become susceptible to apoptosis induction by Fas ligation. We have previously shown that protection from calcium ionophore\u2010 and macromolecular synthesis inhibitor\u2010induced apoptosis by CD40 ligation is associated with a rapid up\u2010regulation of BcI\u2010x<jats:sub>L<\/jats:sub> followed by a more moderate and delayed up\u2010regulation of BcI\u20102. We show here that overexpression of BcI\u2010x<jats:sub>L<\/jats:sub>, like BcI\u20102, protects Ramos cells from apoptosis induction in response to calcium ionophore, anti\u2010Ig and macromolecular synthesis inhibition. However, in contrast to BcI\u20102, ectopic overexpression of BcI\u2010x<jats:sub>L<\/jats:sub> does not rescue from Fas\u2010mediated apoptosis. Thus, in Ramos B cells, the Fas apoptotic pathway exhibits differential sensitivity to inhibition by BcI\u20102 family members. These findings also suggest that CD40 signaling provides a switch which renders the cells susceptible to Fas\u2010ligand mediated apoptosis through up\u2010regulation of Fas whilst affording protection from anti\u2010Ig\u2010induced apoptosis through up\u2010regulation of BcI\u2010x<jats:sub>L<\/jats:sub>.<\/jats:p>","DOI":"10.1002\/eji.1830271249","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T03:59:58Z","timestamp":1172807998000},"page":"3485-3491","source":"Crossref","is-referenced-by-count":15,"title":["Ectopic expression of BcI\u20102, but not BcI\u2010x<sub>L<\/sub> rescues Ramos B cells from Fas\u2010mediated apoptosis"],"prefix":"10.1002","volume":"27","author":[{"given":"Mohammad K.","family":"Alam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Davison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Norton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90309-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(95)80006-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/342929a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80145-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.183.3.971","article-title":"Human germinal center B cells express the apoptosis\u2010inducing genes Fas, c\u2010myc, P53 and Bax but not the survival gene bcl\u20102","volume":"183","author":"Martinez Valdez H.","journal-title":"J. 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