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In the present study, two different rodent models of experimental autoimmune encephalomyelitis (EAE) were used to demonstrate the ability of murine gammaherpesvirus\u201068 (\u03b3HV\u201068) to exacerbate development of neurological symptoms. SJL mice received UV\u2010inactivated \u03b3HV\u201068 or intranasal\u03b3HV\u201068, followed by immunization against proteolipid\u2010protein peptide 139\u2013151. Infected mice became moribund within 10\u2004days post\u2010immunization, whereas mice exposed to UV\u2010inactivated \u03b3HV\u201068 recovered. In the second model, Lewis rats were exposed to UV\u2010inactivated \u03b3HV\u201068 or to \u03b3HV\u201068, followed by passive transfer of encephalitogenic T lymphocytes specific for myelin basic protein. Consistently, infected rats had higher clinical scores, and this result was observed during acute or latent \u03b3HV\u201068 infection. It is unlikely that this \u03b3HV\u201068\u2010induced exacerbation was due to significant viral replication within the central nervous system since nested PCR, viral plaque assays, and infectious\u2010centers assays demonstrated no detectable virus in spinal cords or brains of infected rodents undergoing EAE. Taken together, these studies demonstrate increased clinical symptoms of EAE in rodents infected by a gammaherpesvirus that has a limited ability to invade the central nervous system.<\/jats:p>","DOI":"10.1002\/eji.200323148","type":"journal-article","created":{"date-parts":[[2003,6,11]],"date-time":"2003-06-11T15:09:57Z","timestamp":1055344197000},"page":"1849-1858","source":"Crossref","is-referenced-by-count":41,"title":["Exacerbation of experimental autoimmune encephalomyelitis in rodents infected with murine gammaherpesvirus\u201068"],"prefix":"10.1002","volume":"33","author":[{"given":"James\u2004W.","family":"Peacock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherine\u2004F.","family":"Elsawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia\u2004C.","family":"Petty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William\u2004F.","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth\u2004L.","family":"Bost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,10]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00227-7"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00079-X"},{"key":"e_1_2_7_3_2","first-page":"S141","article-title":"Exogeneous factors in the aetiology of multiple sclerosis.","volume":"6","author":"Granieri E.","year":"2000","journal-title":"J.\u2004Neurovirol."},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90032-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)80008-V"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70257-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109900"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1996.0123"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)81768-4"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.24.3083"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.2.178"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni835"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90016-E"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01208.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830100815"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780036"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80098-2"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(94)90141-4"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(98)01306-7"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)80071-X"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80063-6"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11717"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-2-421"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.863"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-9-2347"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01286.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-11-2635"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.9.1725"},{"key":"e_1_2_7_29_2","first-page":"5894","article-title":"Complete sequence and genomic analysis of murine gammaherpesvirus 68.","volume":"71","author":"Virgin H. 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