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To elucidate the role of IFN\u2010\u03b3 from APC <jats:italic>in vivo<\/jats:italic>, we employed cytokine receptor common \u03b3\u2004subunit (\u03b3c) and recombination\u2010activating gene (Rag)\u20102 double\u2010knockout (\u03b3c<jats:sup>\u2013\/\u2013(y)<\/jats:sup>\u2010Rag\u20102<jats:sup>\u2013\/\u2013<\/jats:sup>) mice, which are severely impaired in IFN\u2010\u03b3 production and are extremely susceptible to infection of intracellular pathogens including<jats:italic> Listeria monocytogenes<\/jats:italic> and <jats:italic>Toxoplasma gondii<\/jats:italic>. Adoptive transfer of IFN\u2010\u03b3\u2010producing APC increased levels of serum IFN\u2010\u03b3 and the resistance to Listeria. Although depletion of NK cells from Rag\u20102<jats:sup>\u2013\/\u2013<\/jats:sup> mice slightly increased the susceptibility to bacterial infection, they are substantially more resistant than \u03b3c<jats:sup>\u2013\/\u2013(y)<\/jats:sup>\u2010Rag\u20102<jats:sup>\u2013\/\u2013<\/jats:sup> mice, which are also devoid of all lymphoid cells. These results demonstrate that the APC\u2010derived IFN\u2010\u03b3 contributes to the control of infectious agents <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.200323292","type":"journal-article","created":{"date-parts":[[2003,9,23]],"date-time":"2003-09-23T22:09:06Z","timestamp":1064354946000},"page":"2666-2675","source":"Crossref","is-referenced-by-count":37,"title":["<i>In vivo<\/i> role of IFN\u2010\u03b3 produced by antigen\u2010presenting cells in early host defense against intracellular pathogens"],"prefix":"10.1002","volume":"33","author":[{"given":"Kazutomo","family":"Suzue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Koyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.50"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80412-2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2494(94)80197-5"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0952-7915(97)80154-9","article-title":"Cytokines acting on or secreted by macrophages during intracellular infection (IL\u201010, IL\u201012, IFN\u2010\u03b3).","volume":"9","author":"Trinchieri G.","year":"1997","journal-title":"Curr. 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