{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:21:40Z","timestamp":1772979700626,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T00:00:00Z","timestamp":1055203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The concept of heterologous T\u2004cell immunity postulates that nonspecific memory T\u2004cells recruited and reactivated in the context of an unrelated virus infection may contribute to protective antiviral immunity. Pulmonary infection with respiratory syncytial virus (RSV) of mice immune to lymphocytic choriomeningitis virus (LCMV) leads to substantial recruitment of systemic LCMV\u2010specific memory CD8 T\u2004cells to the lung. Using a sensitive TCR\u2010transgenic model, we show that such \"bystander\" recruitment to the RSV\u2010infected lung could induce a single round of cell division among LCMV\u2010specific T\u2004cells. However, it did not change their activation status as assessed by expression of surface markers, the extent or kinetics of IFN\u2010\u03b3 production and cytolytic effector function. Moreover,recruitment of LCMV\u2010specific bystander T\u2004cells not only failed to enhance immunity to RSV, but significantly delayed virus elimination and slightly enhanced RSV\u2010induced weight loss in non\u2010transgenic BALB\/c mice. This correlated with a delay in the recruitment of RSV\u2010specific T\u2004cells to the lung. These data show that bystander recruitment of heterologous T\u2004cells is not necessarily accompanied by bystander activation. More importantly, bystander recruitment of systemic memory T\u2004cells can impair antiviral immunity, presumably by interference with the recruitment of specific T\u2004cells.<\/jats:p>","DOI":"10.1002\/eji.200323460","type":"journal-article","created":{"date-parts":[[2003,6,11]],"date-time":"2003-06-11T15:09:57Z","timestamp":1055344197000},"page":"1839-1848","source":"Crossref","is-referenced-by-count":30,"title":["\"Bystander\" recruitment of systemic memory T\u2004cells delays the immune response to respiratory virus infection"],"prefix":"10.1002","volume":"33","author":[{"given":"Tobias","family":"Ostler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Ehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,10]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.1804"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.317"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.4049\/jimmunol.136.4.1186","article-title":"Induction of alloreactive cytotoxic T\u2004cells by acute virus infection of mice.","volume":"136","author":"Yang H.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1933"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.9.1705"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80147-8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2489"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5270.1947"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.1.90"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.5965-5976.2001"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni806"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri820"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.9.1317"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni727"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.12.6983"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.4049\/jimmunol.154.11.6013","article-title":"Recruitment and proliferation of CD8+ T\u2004cells in respiratory virus infections.","volume":"154","author":"Tripp R. A.","year":"1995","journal-title":"J. Immunol."},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.3.1423"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1367"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<284::AID-IMMU284>3.0.CO;2-C"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271240"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/152.4_Pt_2.S59"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200208)32:8<2117::AID-IMMU2117>3.0.CO;2-C"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1629"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.9.1463"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.7.1241"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1749"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220720"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/4.4.493"},{"key":"e_1_2_7_29_2","first-page":"324","article-title":"Flow cytometric analysis of pulmonary lymphocytes from mice infected with respiratory syncytial virus.","volume":"75","author":"Openshaw P. J.","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.2.878-890.2001"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1101-991"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/342559a0"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(02)00191-6"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90236-4"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(01)00455-0"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200109)31:9<2574::AID-IMMU2574>3.0.CO;2-V"},{"key":"e_1_2_7_37_2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1128\/jvi.69.2.1261-1264.1995","article-title":"Cytotoxic T\u2004cells specific for a single peptide on theM2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus.","volume":"69","author":"Kulkarni A. B.","year":"1995","journal-title":"J. Virol."},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190921"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200323460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200323460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:01:01Z","timestamp":1700262061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200323460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,10]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1002\/eji.200323460"],"URL":"https:\/\/doi.org\/10.1002\/eji.200323460","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,10]]}}}