{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:33:00Z","timestamp":1791063180028,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,5,7]],"date-time":"2003-05-07T00:00:00Z","timestamp":1052265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In humans and rodents a population of naturally occurring CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T\u2004cells are suppressor T (CD25<jats:sup>+<\/jats:sup> Ts) cells, which are considered to maintain peripheral immunological tolerance. Recently, we have described a unique chemotactic response profile for human CD25<jats:sup>+<\/jats:sup> Ts cells, but their homing potential remains poorly defined. Here, we document a heterogeneous homing potential of human peripheral blood CD25<jats:bold><jats:sup>+<\/jats:sup><\/jats:bold> Ts cells consistent with their ability to mediate immunosuppression at distinct locations. Surprisingly, CD25<jats:bold><jats:sup>+<\/jats:sup><\/jats:bold>Ts cells are depleted of gut\u2010homing integrin \u03b1<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup>\u03b2<jats:sub>7<\/jats:sub><jats:sup>+<\/jats:sup> T\u2004cells, while being enriched in skin\u2010homing cutaneous lymphocyte antigen (CLA)<jats:sup>+<\/jats:sup> T\u2004cells. These findings document heterogeneous homing potential of peripheral blood\u2010borne CD25<jats:sup>+<\/jats:sup> Ts cells with marked skewing for skin\u2010 versus gut\u2010homing. Expression of CCR4 associates with both CD25 and CLA cell surface markers, being highest on CD4<jats:sup>+<\/jats:sup>CLA<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T\u2004cells. Importantly, CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> Ts cells isolated from human cord blood lack expressionof CLA while expressing CCR4, suggesting intrinsic expression of CCR4 on CD25<jats:bold><jats:sup>+<\/jats:sup><\/jats:bold> Ts cells. These observations indicate that the increased expression of CCR4, which is proposed to guide CD25<jats:sup>+<\/jats:sup> Ts cells to DC, is an intrinsic feature of CD25<jats:sup>+<\/jats:sup> Ts cells.<\/jats:p>","DOI":"10.1002\/eji.200323658","type":"journal-article","created":{"date-parts":[[2003,5,27]],"date-time":"2003-05-27T16:03:22Z","timestamp":1054051402000},"page":"1488-1496","source":"Crossref","is-referenced-by-count":83,"title":["Skin\u2010versus gut\u2010skewed homing receptor expression and intrinsic CCR4 expression on human peripheral blood CD4<sup>+<\/sup>CD25<sup>+<\/sup> suppressor T\u2004cells"],"prefix":"10.1002","volume":"33","author":[{"given":"Andrea","family":"Iellem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Colantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"D'Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,7]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.423"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.11.F41"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80856-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri821"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.5.629"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.295"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.303"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00280-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni759"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.847"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/23495"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.5.761"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2736"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1820102.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2461"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13543"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1553"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60889-5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60022-X"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.627"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80217-4"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.10.040192.003021"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211205"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.4049\/jimmunol.152.7.3282","article-title":"Role of alpha\u20044\u2010integrins in lymphocyte homing to mucosal tissues in vivo.","volume":"152","author":"Hamann A.","year":"1994","journal-title":"J. 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