{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:11:28Z","timestamp":1761127888388},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,5,19]],"date-time":"2003-05-19T00:00:00Z","timestamp":1053302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate whether the increased rate of lymphocyte apoptosis in systemic lupus erythematosus is involved in the onset of the disease, apoptotic or necrotic T or B lymphocytes from variouscell lines were injected intraperitoneally into pre\u2010autoimmune (NZB\u00d7NZW)F1 mice (BW) and non\u2010autoimmune BALB\/c mice. The intraperitoneal production of cytokines and chemokines, the specific T cell response in the spleen, and the production of anti\u2010histone and anti\u2010dsDNA Ab were investigated. The onset of the disease was characterized by creatinine levels and evaluation of glomerular IgG deposits. In BW, but not in BALB\/c mice, injection of apoptotic and not necrotic cells up\u2010regulated IL\u20106 and IL\u201010 in resident macrophages. Administration of apoptotic cells augmented the number of Th2 and B lymphocytes recruited in the peritoneal cavity. Only the treatment with apoptotic B cells promoted a systemic Th2 autoimmune response to H2 histones, associated with earlier occurrence of high levels of anti\u2010dsDNA autoantibodies, higher creatinine levels and more numerous glomerular IgG deposits than in BW controls not injected with apoptotic B cells. In genetically susceptible mice exposure to apoptotic of B, but not T<jats:italic>,<\/jats:italic> lymphocytes can elicit a Th2 response to H2 histones that helps B cell production of anti\u2010dsDNA Ab and finally triggers the onset of lupus.<\/jats:p>","DOI":"10.1002\/eji.200323665","type":"journal-article","created":{"date-parts":[[2003,5,27]],"date-time":"2003-05-27T16:03:22Z","timestamp":1054051402000},"page":"1603-1612","source":"Crossref","is-referenced-by-count":28,"title":["B cell apoptosis accelerates the onset of murine lupus"],"prefix":"10.1002","volume":"33","author":[{"given":"H\u00e9l\u00e8ne","family":"Tr\u00e9b\u00e9den\u2010N\u00e8gre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Weill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Batteux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5,19]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81108-3"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<833::AID-ANR1>3.0.CO;2-T"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1317"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.4049\/jimmunol.152.7.3685","article-title":"Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.","volume":"152","author":"Emlen W.","year":"1994","journal-title":"J. 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