{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:36Z","timestamp":1791174696393,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,4,11]],"date-time":"2003-04-11T00:00:00Z","timestamp":1050019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During murine schistosomiasis, egg\u2010derived glycoconjugates play a key role in skewing the immune response towards a Th2 phenotype. Among the candidates responsible for this effect, complex\u2010type N\u2010glycans containing the core \u03b13\u2010fucose and core \u03b22\u2010xylose determinants, two glycan epitopes found in some invertebrate\u2010 and plant\u2010derived allergens, may be important. Here, we show that core \u03b13\u2010fucose and core \u03b22\u2010xylose determinants are expressed in the different developmental stages of <jats:italic>Schistosoma mansoni<\/jats:italic>, particularly in the excretory\u2010secretory systems of schistosomula and adult worms and in eggs deposited in the liver. Glycosyltransferase assays confirmed the presence of core \u03b13\u2010fucosyltransferase and core \u03b22\u2010xylosyltransferase activities in egg extracts. Using a model of immunization with pulsed dendritic cells, we show that egg\u2010derived glycoproteins containing the core \u03b13\u2010fucose and core \u03b22\u2010xylose determinants generate a strong Th2\u2010biased cellular response in mice and that the glycan moieties of this extract are important in this effect. During murine infection, these complex\u2010type N\u2010glycans induce a glycan\u2010specific Th2 cellular response and elicit T\u2010dependent anti\u2010core \u03b13\u2010fucose and anti\u2010core \u03b22\u2010xylose IgG1 (a Th2\u2010associated isotype), but not IgG2b (a Th1\u2010associated isotype) Ab. Taken together, our results point out theimportance of core fucosylated\/xylosylated N\u2010glycans in the Th2 immune response during murine schistosomiasis.<\/jats:p>","DOI":"10.1002\/eji.200323717","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T16:01:44Z","timestamp":1051718504000},"page":"1271-1281","source":"Crossref","is-referenced-by-count":98,"title":["Schistosome N\u2010glycans containing core \u03b13\u2010fucose and core \u03b22\u2010xylose epitopes are strong inducers of Th2 responses in mice"],"prefix":"10.1002","volume":"33","author":[{"given":"Christelle","family":"Faveeuw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Mallevaey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Paschinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain\u2004B.\u2004H.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella","family":"Mollicone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Oriol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Altmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Lerouge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Capron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Trottein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,11]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.146.4.1322","article-title":"Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.","volume":"146","author":"Grzych J. 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