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We observed that eosinophils from most patients with hypereosinophilia express the \u03b1\u2010chain of the IL\u20102 receptor (CD25), and that IL\u20102 enhances platelet\u2010activating factor\u2010stimulated release ofeosinophil cationic protein from CD25\u2010expressing but not from CD25\u2010negative eosinophils. Such a \"priming\" effect has previously been described for eosinophil hematopoietins. These data suggest thatpatients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL\u20102 is present at inflammatory sites.<\/jats:p>","DOI":"10.1002\/eji.200323727","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T13:58:47Z","timestamp":1048859927000},"page":"834-839","source":"Crossref","is-referenced-by-count":69,"title":["Interleukin\u20102 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome"],"prefix":"10.1002","volume":"33","author":[{"given":"Hans\u2010Uwe","family":"Simon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Pl\u00f6tz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Seitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse\u2004R.","family":"Braathen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Menz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Straumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Dummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Levi\u2010Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,7]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01607-5"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116002"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.4049\/jimmunol.154.10.5481","article-title":"IL\u20108 is expressed by human peripheral blood eosinophils. 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