{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:45:32Z","timestamp":1791117932103,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T00:00:00Z","timestamp":1048464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    IL\u20101\u03b1 and IL\u20101\u03b2 are potent pro\u2010inflammatory cytokines that regulate many physiological systems by binding and signaling to the same receptor termed IL\u20101 receptor type\u20041 (IL\u20101R1). We have investigated the role of IL\u20101 for pulmonary immune responses in models of allergic asthma using IL\u20101R1\u2010deficient (IL\u20101R1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ) mice. In a model of mild asthma, based on repeated sensitization of mice with low doses of ovalbumin in the absence of any adjuvant and multiple intranasal challenges, the pulmonary eosinophilic inflammation and goblet cell hyperplasia were strongly reduced in IL\u20101R1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    as compared to control BALB\/c mice. Moreover, priming of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2004cells in bronchial lymph nodes and their recruitment to the lung was affected in IL\u20101R1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    miceassociated with impaired antibody responses including IgG, IgE, and IgA. In contrast, sensitization of mice in the presence of alum adjuvant, a more severe asthma model, rendered the IL\u20101 pathway dispensable for the development of pulmonary allergic Th2 responses, as eosinophilic inflammation, antibody responses, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2004cell priming in lymph nodes were comparable between IL\u20101R1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    and wild\u2010type mice. These results suggest a critical role of IL\u20101\/IL\u20101R1 for development of allergic Th2 responses, but its requirement can be overcome by using alum as adjuvant for sensitization.\n                  <\/jats:p>","DOI":"10.1002\/eji.200323801","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T08:58:47Z","timestamp":1048841927000},"page":"991-1000","source":"Crossref","is-referenced-by-count":100,"title":["The IL\u20101 receptor\u20041 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model"],"prefix":"10.1002","volume":"33","author":[{"given":"Nicole","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kurrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Kopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,24]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.255"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010113231505"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01492-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.9.825"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.2.9805115"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.4.8887608"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.4049\/jimmunol.149.9.3078","article-title":"Detection of alveolar macrophage\u2010derived IL\u20101 beta in asthma. 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