{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:46:36Z","timestamp":1790930796428,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T00:00:00Z","timestamp":1055203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010liver cytosol type 1 (LC1) autoantibody is detected in 30% of sera from patients with type 2 autoimmune hepatitis (AIH), and is the only circulating autoantibody in 10% of cases. Human formiminotransferase cyclodeaminase (FTCD) has been shown to be the specific liver antigen recognized by anti\u2010LC1 autoantibodies. The aim of this study was to identify the dominant epitope on human FTCD and to analyze antigenic\u2010site sequences for clues on the development of AIH. Recombinant proteins and peptides covering the entire cDNA of human FTCD were tested against anti\u2010LC1 autoantibodies. Conformational epitopes were found throughout the protein but linear epitopes were found exclusively in the C\u2010terminal 146 amino acids. Two groups of sera with different reactivities were found: 69%of the sera recognized two specific linear epitopes at positions 428\u2013434 (NTPEEKD) and 440\u2013447 (LQEGLRRA) of human FTCD; others reacted only with a discontinuous epitope between the amino acids at position 395 and 528. FTCD autoantibody production is thus a polyclonal\u2010antigen\u2010driven B cell response. Autoantibodies against conformational or discontinuous epitopes were found in all patients and two\u2010thirds also recognized linear epitopes on human FTCD.<\/jats:p>","DOI":"10.1002\/eji.200323857","type":"journal-article","created":{"date-parts":[[2003,6,11]],"date-time":"2003-06-11T15:09:57Z","timestamp":1055344197000},"page":"1869-1878","source":"Crossref","is-referenced-by-count":26,"title":["Characterization of the B cell response of patients with anti\u2010liver cytosol autoantibodies in type 2 autoimmune hepatitis"],"prefix":"10.1002","volume":"33","author":[{"given":"Pascal","family":"Lapierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Johanet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,10]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080632"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070626"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199311000-00007"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.5.721"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70186-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.31.19612"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.31.19602"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"22820","DOI":"10.1016\/S0021-9258(18)41601-8","article-title":"The nucleotide sequence of porcine formiminotransferase cyclodeaminase.","volume":"268","author":"Murley L. 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