{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:07:08Z","timestamp":1791248828390,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T00:00:00Z","timestamp":1059955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T00:00:00Z","timestamp":1059955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Several T cell abnormalities have been described in the course of acute\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    infection in mice, including severe effects on the thymus. In the present study, looking at the expression of extracellular matrix ligands in the thymus, we observed that deposits of fibronectin and laminin increased progressively during the course of infection, reaching a maximum at the peak of parasitemia and thymic atrophy. Concomitantly, membrane expression of fibronectin and laminin receptors (VLA\u20104, VLA\u20105 and VLA\u20106) was also enhanced on thymocyte subsets of infected mice. These results correlated with changes in intrathymic thymocyte migration ability during the acute phase of infection, when a higher fibronectin\u2010dependent transmigratory activity of CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    thymocytes was observed. Strikingly, we detected higher frequency of immature and high VLA\u2010expressing CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the peripheral lymphoid organs of infected mice at thepeak of parasitemia. These cells seemed to be thymus dependent, since significantly lower amounts of them were found in thymectomized mice, and some of them carry \u201cprohibited\u201d V\u03b2 segments of the TCR. Our data suggest an imbalance in the intrathymic cell trafficking following acute\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    infection, likely due to dysregulated extracellular matrix\u2010dependent interactions.\n                  <\/jats:p>","DOI":"10.1002\/eji.200323860","type":"journal-article","created":{"date-parts":[[2003,8,21]],"date-time":"2003-08-21T16:41:17Z","timestamp":1061484077000},"page":"2439-2448","source":"Crossref","is-referenced-by-count":45,"title":["<i>Trypanosoma cruzi<\/i>\n                    infection modulates intrathymic contents of extracellular matrix ligands and receptors and alters thymocyte migration"],"prefix":"10.1002","volume":"33","author":[{"given":"Vin\u00edcius","family":"Cotta\u2010de\u2010Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella\u2004Ar\u00eaas","family":"Mendes\u2010da\u2010Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Riederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"de Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia\u2004Regina\u2004Ferreira","family":"Lima\u2010Quaresma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Vieira\u2010de\u2010Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9a\u2004Maria\u2004Serra","family":"Villa\u2010Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,4]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.73"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.4049\/jimmunol.148.6.1595","article-title":"Deletion of antigen\u2010specific immature thymocytes by dendritic cells requires LFA\u20101\/ICAM interactions.","volume":"148","author":"Carlow D. 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