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The description of human patients with inherited IL\u201012 or IL\u201012\u2010receptor deficiency challenges this view. Indeed, in natural conditions of infection and immunity \u2014 the hallmark of the human model \u2014 IL\u201012 was found to be redundant in defense against intracellular microorganisms other than <jats:italic>Mycobacteria<\/jats:italic> and <jats:italic>Salmonella<\/jats:italic>. More surprisingly, IL\u201012 was recently found to be redundant even in defense against primary intection by <jats:italic>Mycobacteria<\/jats:italic> and <jats:italic>Salmonella<\/jats:italic> in many patients, and against secondary infection by <jats:italic>Mycobacteria<\/jats:italic> but not <jats:italic>Salmonella<\/jats:italic> in most patients.<\/jats:p>","DOI":"10.1002\/eji.200324038","type":"journal-article","created":{"date-parts":[[2003,5,27]],"date-time":"2003-05-27T16:03:22Z","timestamp":1054051402000},"page":"1461-1464","source":"Crossref","is-referenced-by-count":135,"title":["Mini\u2010review The role of interleukin\u201012 in human infectious diseases: only a faint signature"],"prefix":"10.1002","volume":"33","author":[{"given":"Claire","family":"Fieschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,7]]},"reference":[{"key":"e_1_2_3_1_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin\u201012 and the regulation of innate resistance and adaptive immunity.","volume":"3","author":"Trinchieri, G.","year":"2003","journal-title":"Nat. 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