{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:56:06Z","timestamp":1788263766944,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T00:00:00Z","timestamp":1059955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T00:00:00Z","timestamp":1059955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Expulsion of the gastro\u2010intestinal nematode\n                    <jats:italic>Trichinella spiralis<\/jats:italic>\n                    is associated with a pronounced mastocytosis mediated by a T helper (Th) 2 type response involving interleukin (IL)\u20104 and IL\u201013. Here we demonstrate that IL\u201010 is a key regulator of protective immune responses against\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    <jats:italic>in vivo<\/jats:italic>\n                    . IL\u201010 knockout mice or normal mice treated with a neutralizing anti\u2010IL\u201010 receptor antibody are highly susceptible to a primary\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    infection and show significantly delayed adult worm expulsion. Depletion of IL\u201010 resulted in elevated Th1 and Th2 cytokine responses but significantly reduced numbers of mucosal mast cells in the jejunum. Interestingly, the increase in IFN\u2010\u03b3 detected in the absence of IL\u201010 resulted in increased immunity to larval stages. Hence, IL\u201010 has a negative effect on immunity to the tissue dwelling larval stages of\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    but plays a significant biological role as an\n                    <jats:italic>in vivo<\/jats:italic>\n                    regulator of intestinal mast cell responses and is crucially involved in protection against adult stages of intestinal parasites\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/eji.200324082","type":"journal-article","created":{"date-parts":[[2003,8,21]],"date-time":"2003-08-21T16:41:17Z","timestamp":1061484077000},"page":"2382-2390","source":"Crossref","is-referenced-by-count":67,"title":["Contrasting roles for IL\u201010 in protective immunity to different life cycle stages of intestinal nematode parasites"],"prefix":"10.1002","volume":"33","author":[{"given":"Helena","family":"Helmby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard\u2004K.","family":"Grencis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,4]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes.","volume":"74","author":"Grencis R. 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