{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:57:13Z","timestamp":1775800633272,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T00:00:00Z","timestamp":1061164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T00:00:00Z","timestamp":1061164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Follicular and marginal zone B\u2004cells constitute the vast majority of mature B\u2004cells in the adult spleen. The inter\u2010relationships between these two functionally and phenotypically distinct subpopulations of B\u2004cells remain unclear. In situations of decreased bone marrow B\u2004lymphopoiesis, the proportion of spleen marginal zone B\u2004cells increases, but the consequence of increasing B\u2004lymphopoiesis on marginal zone B\u2004cells has not been investigated. Using interleukin\u20107\u2010transgenic mice, in which B\u2004lymphopoiesis is significantly increased, we show that the number of follicular B\u2004cells increased about fivefold but the number of marginal zone B\u2004cells decreased. Functional and phenotypic analysis, including\n                    <jats:italic>in vivo<\/jats:italic>\n                    bromodeoxyuridine labeling experiments, showed that marginal zoneB\u2004cells in transgenic mice were indistinguishable from controls. Mixed radiation bone marrow chimeras showed that marginal zone B\u2004cells developed equally well from both normal and transgenic adult bone marrow B\u2004cell progenitors. Taken together, these results suggest that interleukin\u20107 does not influence the lineage choice between follicular and marginal zone B\u2004cells and that the number of cells ineach compartment is independently regulated.\n                  <\/jats:p>","DOI":"10.1002\/eji.200324134","type":"journal-article","created":{"date-parts":[[2003,8,21]],"date-time":"2003-08-21T16:41:17Z","timestamp":1061484077000},"page":"2567-2576","source":"Crossref","is-referenced-by-count":17,"title":["In interleukin\u20107\u2010transgenic mice, increasing B\u2004lymphopoiesis increases follicular but not marginal zone B\u2004cell numbers"],"prefix":"10.1002","volume":"33","author":[{"given":"Rhodri","family":"Ceredig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice\u2004N.","family":"Maye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonius","family":"Rolink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,18]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri799"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb00958.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830161216"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270935"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111103"},{"key":"e_1_2_7_6_2","first-page":"139","article-title":"Comparative analysis of the development of B cells in marginal zones and follicles.","volume":"186","author":"MacLennan I. 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