{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:08:43Z","timestamp":1789898923870,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,1,20]],"date-time":"2004-01-20T00:00:00Z","timestamp":1074556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The NOD mouse has proved to be a relevant model of insulin\u2010dependent diabetes mellitus, closely resembling the human disease. However, it is unknown whether this strain presents a general biastoward Th1\u2010mediated autoimmunity or remains capable of mounting complete Th2\u2010mediated responses. Here, we show that NOD mice have the capacity to develop a typical Th2\u2010mediated disease, namely experimental allergic asthma. In contrast to what might have been expected, they even developed a stronger Th2\u2010mediated pulmonary inflammatory response than BALB\/c mice, a strain that shows a typical Th2 bias in this model. Thus, after allergen sensitization and intra\u2010nasal challenge, the typical features of experimental asthma were exacerbated in NOD mice, including enhanced bronchopulmonary responsiveness, mucus production and eosinophilic inflammation in the lungs as well as specific IgE titers in serum. These hallmarks of allergic asthma were associated with increased IL\u20104, IL\u20105, IL\u201013 and eotaxin production in the lungs, as compared with BALB\/c mice. Notwithstanding their quantitative and functional defect in NOD mice, CD1d\u2010dependent NKT cells contribute to aggravate the disease, since in OVA\u2010immunized CD1d\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    NOD mice, which are deficient in this particular T cell subset, airway eosinophilia was clearly diminished relative to NOD littermates. This is the first evidence that autoimmune diabetes\u2010prone NOD mice can also give rise to enhanced Th2\u2010mediated responses and might thus provide a useful model for the study of common genetic and cellular components, including NKT cells that contribute to both asthma and type\u20041 diabetes.\n                  <\/jats:p>","DOI":"10.1002\/eji.200324151","type":"journal-article","created":{"date-parts":[[2004,2,4]],"date-time":"2004-02-04T07:00:38Z","timestamp":1075878038000},"page":"327-335","source":"Crossref","is-referenced-by-count":37,"title":["Exacerbated Th2\u2010mediated airway inflammation and hyperresponsiveness in autoimmune diabetes\u2010prone NOD mice: a critical role for CD1d\u2010dependent NKT cells"],"prefix":"10.1002","volume":"34","author":[{"given":"Luiza\u2004M.","family":"Araujo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Lefort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Anne","family":"Nahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Diem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2004C.","family":"Leite\u2010de\u2010Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2004F.","family":"Bach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.\u2004Boris","family":"Vargaftig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Herbelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,3]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim1978.29.1_1"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-15-4-516"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.131"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80392-1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7761837"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80068-9"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2205920"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118006"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.2.817"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.4049\/jimmunol.154.9.4874","article-title":"IFN\u2010gamma gene expression in pancreatic islet\u2010infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.","volume":"154","author":"Rabinovitch A.","year":"1995","journal-title":"J. Immunol."},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.4049\/jimmunol.158.5.2414","article-title":"IL\u20104 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice.","volume":"158","author":"Fox C. J.","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(91)90021-4"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270930"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.87"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.1093"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.11.6564"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.12.2039"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.5.3446"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00003.x"},{"key":"e_1_2_7_20_2","first-page":"340","article-title":"Bronchopulmonary hyperreactivity and lung eosinophil sequestration but not their migration to the alveolar compartment are independent of interleukin\u20105 in allergic mice.","volume":"13","author":"Proust B.","year":"2002","journal-title":"Eur. CytokineNetw."},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.6.4351"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.183"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2258"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm851"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1637"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830261226"},{"key":"e_1_2_7_27_2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.2337\/diab.46.4.572","article-title":"Association between alphabetaTCR+CD4\u2013CD8\u2013 T cell deficiency and IDDM in NOD\/Lt mice.","volume":"46","author":"Baxter A. G.","year":"1997","journal-title":"Diabetes"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0901-1057"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90011-6"},{"key":"e_1_2_7_30_2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.4049\/jimmunol.161.3.1501","article-title":"A novel T cell\u2010regulated mechanism modulating allergen\u2010induced airway hyperreactivity in BALB\/c mice independently of IL\u20104 and IL\u20105.","volume":"161","author":"Hogan S. P.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1527"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.207"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7631"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm745"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01450-2"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0802-715"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0602-625"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6007"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0901-1052"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04067-8"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1159\/000060527"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200324151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200324151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T05:50:02Z","timestamp":1700200202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200324151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1002\/eji.200324151"],"URL":"https:\/\/doi.org\/10.1002\/eji.200324151","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1017473.204251","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}