{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:41Z","timestamp":1791404921651,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2003,11,10]],"date-time":"2003-11-10T00:00:00Z","timestamp":1068422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The pathogenesis of human asthma and the development of key features of pulmonary allergy in mouse models has been critically linked to IL\u201013. Analyses of the receptor components employed by IL\u201013 have shown that delivery of this cytokine to the airways of naive IL\u20104R\u03b1 gene targeted (IL\u20104R\u03b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ) mice fails to induce disease, suggesting that this membrane protein is critical for transducing IL\u201013\u2010mediated responses. The current study demonstrates that, in contrast to naive mice, T helper 2 bias, airways hyperreactivity (AHR) and tissue eosinophilia develop in Ovalbumin\u2010sensitized IL\u20104R\u03b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice and that these responses can be inhibited by the IL\u201013 antagonist sIL\u201013R\u03b12Fc. Therefore, antigen stimulation induces an IL\u201013\u2010regulated response that is independent of IL\u20104R\u03b1. To determine the role of IL\u20105 and eosinophils in the development of disease in antigen\u2010exposed IL\u20104R\u03b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, pulmonary allergy was examined in mice deficient in both factors. IL\u20104R\u03b1\/IL\u20105\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice were significantly defective in their ability to produce IL\u201013 and failed to develop AHR, suggesting that IL\u20105 indirectly regulates AHR in allergic IL\u20104R\u03b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice by an IL\u201013\u2010dependent mechanism. Collectively, these results demonstrate that IL\u201013\u2010dependent processes regulating the development of AHR and T helper bias persist in the inthe lungs of allergic IL\u20104R\u03b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice.\n                  <\/jats:p>","DOI":"10.1002\/eji.200324178","type":"journal-article","created":{"date-parts":[[2003,11,20]],"date-time":"2003-11-20T13:07:53Z","timestamp":1069333673000},"page":"3377-3385","source":"Crossref","is-referenced-by-count":32,"title":["Antigen\u2010specific production of interleukin (IL)\u201013 and IL\u20105 cooperate to mediate IL\u20104R\u03b1\u2010independent airway hyperreactivity"],"prefix":"10.1002","volume":"33","author":[{"given":"Dianne\u2004C.","family":"Webb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendran","family":"Mahalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeping","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus\u2004I.","family":"Matthaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra\u2004D.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u2004S.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,10]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90251-I"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260504"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90026-4"},{"key":"e_1_2_7_4_2","first-page":"368","article-title":"Interleukin\u201013 and interleukin\u20104 are coexpressed in atopic asthma.","volume":"108","author":"Kotsimbos T. 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