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Here, mimotopes of a shared tumor\u2010associated T cell epitope in cutaneous lymphoma were tested for their capacities to induce clinical and immunological responses in cancer patients. The mimotope sequences had been determined by a combinatorial peptide library approach without knowledge of the corresponding natural tumor\u2010associated antigen. Vaccination with these mimotopes together with helper T cell\u2010inducing antigens led to complete tumor remission in the two patients tested. After each booster vaccination, enhanced frequencies of mimotope\u2010specific CD8<jats:sup>+<\/jats:sup> T cells were detected in the peripheral blood of the patients, and the CTL proved to be cytotoxic and tumoricidal when tested <jats:italic>in vitro<\/jats:italic>. These data provide a first indication of clinical efficacy of mimotopes in cancer patients.<\/jats:p>","DOI":"10.1002\/eji.200324244","type":"journal-article","created":{"date-parts":[[2003,10,22]],"date-time":"2003-10-22T19:30:16Z","timestamp":1066851016000},"page":"3175-3185","source":"Crossref","is-referenced-by-count":22,"title":["Anti\u2010tumor immune responses and tumor regression induced with mimotopes of a tumor\u2010associated T cell epitope"],"prefix":"10.1002","volume":"33","author":[{"given":"Sherev","family":"Tumenjargal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylke","family":"Gellrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Linnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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