{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:15:34Z","timestamp":1791065734859,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,3]],"date-time":"2004-02-03T00:00:00Z","timestamp":1075766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although NKT cells have been found to be capable of modulating immune responses in several model systems, the role of NKT cells in allergy remains unclear. Using CD1 gene knockout (KO) mice, which lack NKT cells, we examined the function of NKT cells in the development of allergic inflammation induced by a common airborne human allergen, ragweed. The data showed that airway eosinophilia and mucus overproduction induced by ragweed were significantly reduced in CD1 KO mice, which was correlated with significantly lower allergen\u2010driven IL\u20104 production and lower eotaxin responses in the airways of CD1 KO mice. Moreover, both ragweed\u2010specific and total serum IgE levels in CD1 KO mice were significantly lower than those in control BALB\/c mice. The reduced allergic reaction in CD1 KO mice is not due to intrinsic deficiency because they showed normal levels of immune cells and function. In addition, <jats:italic>in vivo<\/jats:italic> stimulation of NKT cells using their natural ligand, \u03b1\u2010galactosylceramide, enhanced ragweed\u2010induced airway eosinophilia, IL\u20104, and eotaxin production in control, but not CD1 KO mice. These data provide <jats:italic>in vivo<\/jats:italic> evidence for the involvementof NKT cells in the allergic mechanisms responsible for allergen\u2010driven cytokine and chemokine production and airway inflammation.<\/jats:p>","DOI":"10.1002\/eji.200324303","type":"journal-article","created":{"date-parts":[[2004,2,4]],"date-time":"2004-02-04T12:00:38Z","timestamp":1075896038000},"page":"345-354","source":"Crossref","is-referenced-by-count":66,"title":["Natural killer T cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL\u20104 and eotaxin production"],"prefix":"10.1002","volume":"34","author":[{"given":"Laura","family":"Bilenki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,3]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7538697"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)80582-2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3768::AID-IMMU3768>3.0.CO;2-G"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.535"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011544"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(00)01735-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1507::AID-IMMU1507>3.0.CO;2-F"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01326.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2412"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4049\/jimmunol.163.1.93","article-title":"A novel function of V\u03b114+CD4+ NKT cells: stimulation of IL\u201012 production by antigen\u2010presenting cells inthe innate immune system.","volume":"163","author":"Tomura M.","year":"1999","journal-title":"J. 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