{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:54:43Z","timestamp":1790427283214,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,3]],"date-time":"2004-02-03T00:00:00Z","timestamp":1075766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin\u201010 (IL\u201010), originally identified as an inhibitor of pro\u2010inflammatory cytokine production, exerts multiple immunomodulatory functions. Its ability to inhibit a Th1 response has been used in clinical trials for the treatment of inflammatory diseases including psoriasis. However, little is known about the molecular mechanisms of IL\u201010 functions. We aimed at identifying possiblemediators of <jats:italic>in vitro<\/jats:italic> IL\u201010 treatment in monocytes by gene chip technology using Hu95a Affymetrix mRNA arrays with\u200412,000 genes. To prove relevance of the identified genes for the clinicalsituation we compared these <jats:italic>in vitro<\/jats:italic> results with genes being regulated by IL\u201010 in peripheral blood mononuclear cells from psoriatic patients undergoing IL\u201010 therapy. A high proportion of the 1,600\u2004genes up\u2010regulated and 1,300 genes down\u2010regulated <jats:italic>in vitro<\/jats:italic> was found to be similarly regulated <jats:italic>in vivo<\/jats:italic>. Some genes, which were previously unknown to be regulated by IL\u201010, can be assigned to known IL\u201010 functions like <jats:italic>e.g.<\/jats:italic> the increase of pathogen clearance. Other new potentially immunomodulating genes have been identified to be regulated by IL\u201010, but their impact needs to be experimentally evaluated. We could confirm a recently reported up\u2010regulation of heme oxygenase\u20101 (HO\u20101). However, we demonstrate that the anti\u2010inflammatory mechanisms of IL\u201010 remain functional even when HO\u20101 is irreversibly inhibited.<\/jats:p>","DOI":"10.1002\/eji.200324323","type":"journal-article","created":{"date-parts":[[2004,2,4]],"date-time":"2004-02-04T12:00:38Z","timestamp":1075896038000},"page":"481-493","source":"Crossref","is-referenced-by-count":73,"title":["Expression profiling of IL\u201010\u2010regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL\u201010 therapy"],"prefix":"10.1002","volume":"34","author":[{"given":"Mechthild","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sabat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Kr\u00e4tzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Sch\u00f6nbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Sch\u00fctt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf\u2010Dietrich","family":"D\u00f6cke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khusru","family":"Asadullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Dieter","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Gr\u00fctz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,3]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.915"},{"key":"e_1_2_7_4_2","first-page":"78","article-title":"Interleukin\u201010 drives humanmonocytes to CD16 positive macrophages.","volume":"46","author":"Calzada\u2010Wack J. 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