{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:01:18Z","timestamp":1777417278313,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,9,22]],"date-time":"2004-09-22T00:00:00Z","timestamp":1095811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endothelial selectins are crucial for the recruitment of leukocytes into sites of inflammation. On T\u2004cells, ligands for selectins become induced upon differentiation into the effector\/memory stage. Initial <jats:italic>in vitro<\/jats:italic> studies suggested a correlation between the Th1 phenotype and ligand expression, but whether this also holds true <jats:italic>in vivo <\/jats:italic>remained uncertain. We here analyzed selectin ligands on CD4<jats:sup>+<\/jats:sup> T\u2004cells producing IFN\u2010\u03b3, IL\u20104 or IL\u201010, prototypic cytokines of the Th1, Th2 and Tr1 subset, respectively. We analyzed mice infected with influenza virus, the bacterium <jats:italic>Listeria,<\/jats:italic> and the parasites <jats:italic>Toxoplasma<\/jats:italic> (all Th1 models) or <jats:italic>Nippostrongylus<\/jats:italic> (Th2 model). A link between the Th1 phenotype and ligand expression was not found <jats:italic>in vivo<\/jats:italic>. Surprisingly, the potentially regulatory IL\u201010\u2010producing T\u2004cells displayed the highest frequency of ligand\u2010positive cells in general. Within the inflamed tissues, the frequencies of P\u2010selectin\u2010binding cells increased in the dominant subset, either Th1 or Th2. Up\u2010regulation was also found for E\u2010selectin ligands during influenza, but not <jats:italic>Nippostrongylus<\/jats:italic> infection. In conclusion, conditions driving T\u2004cell polarization into either Th1 or Th2 <jats:italic>in vivo<\/jats:italic> do not affect the expression of selectin ligands, but acquisition of P\u2010selectin binding and hence migration into inflamed tissues is boosted by an inflammatory milieu.<\/jats:p>","DOI":"10.1002\/eji.200424972","type":"journal-article","created":{"date-parts":[[2004,9,22]],"date-time":"2004-09-22T13:04:47Z","timestamp":1095858287000},"page":"3070-3081","source":"Crossref","is-referenced-by-count":22,"title":["Expression of selectin ligands on murine effector and IL\u201010\u2010producing CD4<sup>+<\/sup> T\u2004cells from non\u2010infected and infected tissues"],"prefix":"10.1002","volume":"34","author":[{"given":"Ute","family":"Kretschmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Bonhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun\u2004F.","family":"Debes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Willi","family":"Mittr\u00fccker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2004J.","family":"Erb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Liesenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Zaiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kamradt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Syrbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alf","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/39614"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.f53"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.4049\/jimmunol.161.2.963","article-title":"CD4+ T\u2004cells only migrate into inflamed skin if they express ligands for E\u2010 and P\u2010selectin.","volume":"161","author":"Tietz W.","year":"1998","journal-title":"J. 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