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Here, we report the initial characterization of a new mouse model with selective Ig deficiency. SENCARA mice display low serum IgG3 levels as well as severely deficient IgG3 responses to T\u2004cell\u2010independent (TI) type\u20041 and 2 antigens. However, despite the significant block in class switching, expression of activation\u2010induced deaminase and \u03b33 germ\u2010line transcription after TI antigen immunization are normal. IgG3 production in response to <jats:italic>in vitro<\/jats:italic> LPS stimulation was also normal, ruling out a specific defect in the C\u03b33 switch machinery. A decrease in the number of peritoneal B1a cells and enlarged splenic marginal zones were observed. The immunodeficiency is inherited as an autosomal, semi\u2010dominant, essentially monogenic trait in SENCARA\u2004\u00d7\u2004C57BL\/6 crosses. The SENCARA humoral immunodeficiency constitutes a novel immune phenotype, resembling human conditions such as IgG2 deficiency. This new mouse model will be of interest for the understanding of mechanisms involved in TI immune responses and may provide new insights into the molecular basis of human Ig deficiencies.<\/jats:p>","DOI":"10.1002\/eji.200425060","type":"journal-article","created":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T16:01:51Z","timestamp":1085500911000},"page":"1807-1816","source":"Crossref","is-referenced-by-count":4,"title":["A new murine model of humoral immuno\u2010deficiency specifically affects class switching to T\u2010independent antigens"],"prefix":"10.1002","volume":"34","author":[{"given":"Igor\u2004I.","family":"Kuzin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory\u2004D.","family":"Ugine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard\u2004K.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard\u2004D.","family":"Shultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u2004H.","family":"Nahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith\u2004M.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bottaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,15]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199312000-00010"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199412000-00011"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60744-0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.122466"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2001.0185"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10050"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.02004.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02253.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1987.tb01063.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90197-C"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115094"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/300760a0"},{"key":"e_1_2_7_13_2","first-page":"55","article-title":"Gene deletions within the human immunoglobulin heavy chain constant region gene cluster.","volume":"6","author":"Bottaro A.","year":"1989","journal-title":"Exp. 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