{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:05:49Z","timestamp":1772118349498,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Little is currently understood about the consequences of chronic parasitic infection for the fate of memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2004cells that recognize heterologous antigens,\n                    <jats:italic>e.g.<\/jats:italic>\n                    resulting from prior infections or vaccination. Here, we address how\n                    <jats:italic>Leishmania donovani<\/jats:italic>\n                    infection affected the fate of non\u2010cross\u2010reactive (OVA)\u2010specific memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2004cells. DO11 cells were adoptively transferred into naive recipient mice, which were then immunized to generate memory DO11 cells. After 6\u2004weeks, mice were infected with\n                    <jats:italic>L. donovani<\/jats:italic>\n                    and the fate of DO11 cells was determined.\n                    <jats:italic>L. donovani<\/jats:italic>\n                    infection stimulated an approximately threefold expansion in the total number of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2004cells and DO11 cells, compared to that observed in uninfected mice. DO11 T\u2004cells were more actively dividing in infected mice, as judged by 5\u2010bromo\u20102\u2032 deoxyuridine labeling, whereas their rate of apoptosis in control and infected mice was identical. Both CD45RB\n                    <jats:sup>hi<\/jats:sup>\n                    CD44\n                    <jats:sup>lo<\/jats:sup>\n                    naive T\u2004cells and to a greater extent CD45RB\n                    <jats:sup>lo<\/jats:sup>\n                    CD44\n                    <jats:sup>hi<\/jats:sup>\n                    memory DO11 cells increased in number in the spleens of infected mice, whereas no changes occurred to DO11 cell number or phenotype in the draining lymph nodes. These data indicate that heterologous CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2004cells may actively divide during chronic infectious diseases, with important implications for how chronic infection may impact on heterologous immunity.\n                  <\/jats:p>","DOI":"10.1002\/eji.200425436","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T08:18:55Z","timestamp":1106900335000},"page":"498-504","source":"Crossref","is-referenced-by-count":17,"title":["The fate of heterologous CD4\n                    <sup>+<\/sup>\n                    T\u2004cells during\n                    <i>Leishmania donovani<\/i>\n                    infection"],"prefix":"10.1002","volume":"35","author":[{"given":"Rosalind","family":"Polley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soombul","family":"Zubairi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul\u2004M.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,28]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri778"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/369652a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2057"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80091-6"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/90643"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5443.1381"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.7.3640"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1052"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2489"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1197"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01549-2"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<687::AID-IMMU687>3.0.CO;2-N"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.0105"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm933"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.2001.00199.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.4049\/jimmunol.158.8.3813","article-title":"Destruction of follicular dendritic cells during chronic visceral leishmaniasis.","volume":"158","author":"Smelt S. 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