{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:48:47Z","timestamp":1790704127824,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T00:00:00Z","timestamp":1135036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The family of IL\u201010\u2010related cytokines includes several human members, IL\u201019, IL\u201020, IL\u201022, IL\u201024 and IL\u201026, and a series of herpesviral and poxviral paralogs. Some of these cytokines share common receptor subunits. In this study, we investigated the effects of these cytokines on naive T cell differentiation, antigen\u2010specific T cell suppression, survival ad expression of surface markers in comparison to IL\u201010 and cytomegalovirus (CMV)\u2010IL\u201010. Human CD45RA<jats:sup>+<\/jats:sup> T cells were stimulated in the presence of IL\u201010\u2010family cytokines in sequential 12\u2010day cycles. After three to four cycles of stimulation, IL\u201010 and CMV\u2010IL\u201010 led to increased IFN\u2010\u03b3 and IL\u201010 but decreased IL\u20104 and IL\u201013. Interestingly, long\u2010term exposure of T cells to IL\u201019, IL\u201020 and IL\u201022 down\u2010regulated IFN\u2010\u03b3 but up\u2010regulated IL\u20104 and IL\u201013 in T cells and supported the polarization of naive T cells to Th2\u2010like cells. In contrast, neutralization of endogenous IL\u201022 activity by IL\u201022\u2010binding protein decreased IL\u20104, IL\u201013 and IFN\u2010\u03b3 synthesis. The antigen\u2010specific suppressor activity of IL\u201010 and CMV\u2010IL\u201010 was not observed for any of the other IL\u201010\u2010family cytokines. These data demonstrate that IL\u201019, IL\u201020 and IL\u201022 may participate in T cell\u2010mediated diseases by distinct regulation of T cell cytokine profiles.<\/jats:p>","DOI":"10.1002\/eji.200425523","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T13:21:38Z","timestamp":1135084898000},"page":"380-388","source":"Crossref","is-referenced-by-count":117,"title":["Regulation of T cells and cytokines by the interleukin\u201010 (IL\u201010)\u2010family cytokines IL\u201019, IL\u201020, IL\u201022, IL\u201024 andIL\u201026"],"prefix":"10.1002","volume":"36","author":[{"given":"Haluk\u2004B.","family":"Oral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei\u2004V.","family":"Kotenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Zumkehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Blaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezmi\u2004A.","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcbeccel","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,2]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14620"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.915"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1890"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.2.507"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2658::AID-IMMU2658>3.0.CO;2-G"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.99-0874fje"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00348.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01919-3"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02149-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4288"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205114200"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00187-8"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5397"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00312-8"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.1814"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.170291697"},{"key":"e_1_2_7_19_2","first-page":"5","article-title":"Viral and cellular interleukin\u201010 (IL\u201010)\u2010related cytokines: from structures to functions.","volume":"13","author":"Dumoutier L.","year":"2002","journal-title":"Eur. Cytokine Netw."},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/107999001317205178"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7090"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.01.010"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171303198"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7096"},{"key":"e_1_2_7_25_2","first-page":"2477","article-title":"Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda\u20107, modulated during human melanoma differentiation, growth and progression.","volume":"11","author":"Jiang H.","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.01.017"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1437"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1695"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0538"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000067596"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.9.5530"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200208)32:8<2237::AID-IMMU2237>3.0.CO;2-2"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1820105.x"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032058"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7520605"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/39614"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000106468.96542.26"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1178"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.3.1285-1292.2002"},{"key":"e_1_2_7_40_2","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.4049\/jimmunol.156.7.2413","article-title":"High\u2010dose IL\u20102 and IL\u201015 enhance the in vitro priming of naive CD4+ T cells for IFN\u2010gamma but have differential effects on priming for IL\u20104.","volume":"156","author":"Seder R. A.","year":"1996","journal-title":"J. Immunol."},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363714"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6712"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.01.007"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.3545"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.01.005"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007837200"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005304200"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2006"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364144"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200006)30:6<1683::AID-IMMU1683>3.0.CO;2-A"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324815"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.5007"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2250"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011629"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200322919"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200425523","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200425523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:25:24Z","timestamp":1697153124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200425523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1002\/eji.200425523"],"URL":"https:\/\/doi.org\/10.1002\/eji.200425523","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}